Process for the fermentative preparation of D-pantothenic acid and/or its salts
AssigneeDegussa AG
InventorsMechthild Rieping, Thomas Hermann
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Abstract
A method br the fermentative preparation of D-pantothenic acid and/or its salts or feedstuff additives containing these. Said method comprising fermentation of Escherichia coli microorganisms wherein at least one of the nucleotide sequence(s) coding for the gcvT, gcvH, and gcvP gene is overexpressed.
Claims13
A method of producing D-pantothenic acid and/or a salt thereof, comprising:
- fermenting a microorganism of the family Enterobacteriaceae, in which at least one of the nucleotide sequences in the microorganism coding for endogenic genes selected from the group consisting of gcvT, gcvH, and gcvP is overexpressed in a medium suitable for the production of the corresponding gene products, wherein the microorganism is Escherichia coli and produces the D-pantothenic acid and/or a salt thereof.
A method for producing D-pantothenic acid and/or its salts by the fermentation of an Escherichia coli microorganism transformed with a vector containing a promotor operably linked to an Escherichia coli gene selected from the group consisting of gcvT, gcvH, and gcvP.
A method for producing D-pantothenic acid and/or its salts by the fermentation of an Escherichia coli microorganism transformed with the plasmid pTrc99AgcvT.
Dependencies are inferred from the claim text.