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AssigneeAventis
InventorKlaus Bartsch
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Process for the preparation of L -amino acids from their racemic N-acetyl-D,L derivatives by enzymatic resolution by means of isolated, recombinant enzymes A process for the preparation of proteinogenic or nonproteinogenic L-amino acids, in particular L-phosphinothricin, from their racemic N-acetyl-D,L derivatives comprises a) selectively deacetylating N-acetyl-L derivatives of the corresponding L-amino acids by an enzymatic resolution by means of isolated, recombinant enzymes, while N-acetyl-D derivatives of the corresponding D-amino acids are not deacetylated and (b) separating the deacetylated L-amino acids obtained preparatively from the nondeacetylated N-acetyl-D derivatives and/or the incompletely deacetylated N-acetyl-L derivatives.
A process for the preparation of proteinogenic or nonproteinogenic L-amino acids form their racemic N-acetyl-D,L-derivatives, which comprises:
A method for the enantioselective production of one or more L-amino acids from their corresponding N-acetyl-D,L derivatives, comprising the step of utilizing one or more isolated, recombinant hippurate hydrolases and the subsequent separation of the L-amino acids from incompletely deacetylated N-acetyl-L-amino acids and from non-deacetylated N-acetyl-L-amino acids.
A method for the enantioselective production of L-phosphinothricin, L-glutamic acid, L-histidine, L-leucine, L-glutamine and/or L-phenylalanine from their corresponding N-acetyl-D,L derivatives, comprising the step of utilizing one or more isolated, recombinant hippurate hydrolases and the subsequent separation of the L-amino acids from incompletely deacetvlated N-acetyl-L-amino acids and from non-deacetylated N-acetyl-L-amino acids.
A method for the enantioselective production of one or more L-amnino acids from their corresponding racemic N-acetyl-D,L derivatives, comprising the step of utilizing isolated, recombinant deac1 from Stenotrophomonas sp. and/or deac2 from Comamonas acidovorans and the subsequent separation of the L-amino acids from incompletely deacetylated N-acetyl-L-amino acids and from non-deacetylated N-acetyl-L-amino acids.
A method for the enantioselective production of L-phosphinothricin, L-glutamic acid, L-histidine, L-leucine, L-glutamine, L-phenylalanine from their corresponding racemic N-actyl-D,L derivatives, comprising the step of utilizing isolated, recombinant deac1 from Stenotrophomonas sp. and/or deac2 from Comamonas acidovorans and the subsequent separation of the L-amino acids from incompletely deacetylated N-acetyl-L-amino acids and from non-deacetylated N-acetyl-L-amino acids.
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