Fusion polypeptides of human serum albumin and a therapeutically active polypeptide
AssigneeAventis Behring GmbH
InventorsReinhard Fleer, Alain Fournier, Jean-Dominique Guitton, Gérard Jung, Patrice Yeh
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Abstract
Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.
Claims25
A fusion protein comprising erythropoietin and albumin or an albumin variant, wherein said fusion protein has a higher plasma stability than unfused erythropoietin, and wherein said albumin or albumin variant is located either at the N-terminus or C-terminus of said fusion protein.
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