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US 6,686,153 B1Granted
PRV-1 gene and the use thereof
AssigneeUniversitatsklinikum Freiburg
InventorHeike Pahl
Life of this patent
Estimating the term…
Abstract
This document describes a nucleotide sequence which encodes the PRV-1 protein, and essentially comprises the sequence ID No. 1, and also a process for detecting this gene and the polypeptide encoded by this gene.
Claims21
An isolated polypeptide, comprising one of the following amino acid sequences:
- amino acids 1-437 of SEQ. ID NO.:
- 2;
- amino acids 1-409 of SEQ. ID NO.:
- 2;
- amino acids 22-437 of SEQ. ID NO.:
- 2;
- amino acids 22-409 of SEQ. ID NO.:
- 2;
- or a antigenic fragment thereof containing at least 50 amino acids.
6 more elements
An isolated polypeptide, comprising one of the following amino acid sequences:
- amino acids 1-437 of SEQ. ID NO.:
- 2;
- amino acids 1-409 of SEQ. ID NO.:
- 2;
- amino acids 22-437 of SEQ. ID NO.:
- 2;
- or
- amino acids 22-409 of SEQ. ID NO.:
- 2.
6 more elements
An isolated polypeptide comprising the amino acid sequence of SEQ. ID NO.:
- 2.
An isolated polynucleotide, comprising one of the following nucleotide sequences:
- nucleotides 1-1600 of SEQ. ID NO.:
- 1;
- nucleotides 36-1346 of SEQ. IDNO.:
- 1;
- nucleotides 36-1262 of SEQ. ID NO.:
- 1;
- nucleotides 39-1346 of SEQ. ID NO.:
- 1;
- nucleotides 39-1262 of SEQ. ID NO.:
- 1;
- nucleotides 99-1346 of SEQ. ID NO.:
- 1;
- or
- nucleotides 99-1262 of SEQ. ID NO.:
- 1.
12 more elements
A method of diagnosing polycythaemia vera in a human subject, comprising,
- detecting expression of a polynucleotide coding for human PRV-1 in a blood sample comprising granulocytes, whereby the presence of said expressed polynucleotide in said cells is diagnostic of polycythaemia vera.
Dependencies are inferred from the claim text.