Prognostic methods for prediction of progression of normal and hyperplastic mammary cells to carcinoma
AssigneeCalifornia Pacific Medical Center
InventorsGuoren Deng, You Lu, Helene S. Smith
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Abstract
The present invention encompasses methods for determining the likelihood that benign hyperplastic breast tissue or normal breast tissue adjacent to carcinoma tissue will become malignant. The methods comprise substantially isolating the tissue; and determining loss of heterozygosity (LOH) at chromosome 3p24 in the tissue. LOH at chromosome 3p24 is a prognostic indicator that the tissue may become malignant.
Claims14
A method for determining the likelihood of tissue in a human subject becoming malignant where the tissue is adjacent to breast carcinoma, comprising obtaining a sample of tissue adjacent to the carcinoma;
- determining a loss heterozygosity (LOH) at chromosome locus 3p2A in non-malignant tissue in the sample and correlating the LOH at chromosome locus 3p24 in non-malignant tissue in the sample with increased risk that the tissue in the human subject will become malignant.
Dependencies are inferred from the claim text.