Pharmaceutical compositions comprising 2-isoxazoles-8-aminotetralin derivatives
AssigneeSociete de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
InventorsJacques Pierre Moreau, Béatrice Guimbert, Marc Pellet
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Abstract
The invention relates to novel pharmaceutical compositions comprising 2-isoxazole-8-aminotetralin derivatives. The invention more specifically relates to compositions in the form of a patch comprising a therapeutically efficacious amount of a derivative of 2-isoxazole-8-aminotetraline, especially 1,2,3,4-tetrahydro-8(5-isoxazolyl)N-N-diisopropyl-2-naphtalenamine. The invention also relates to a 2-isoxazole-8-aminotetralin derivative, especially 1,2,3,4-tetrahydro-8-(5-isoxazolyl)-N,N-diisopropyl-2-naphtalenamine, which is used to produce a medicament which can be administered transdermally to treat irritable bowel syndrome.
Claims11
A matrix or reservoir pharmaceutical composition for topical administration of at least one derivative of 8-isoxazole-2-aminotetraline in a therapeutically effective amount, a plasticizer agent and at least one pharmaceutically acceptable polymer or copolymer excipient in the form of a patch.
A matrix or reservoir pharmaceutical composition for topical administration of at least one derivative of 8-isoxazole-2-aminotetraline in a therapeutically effective amount and at least one pharmaceutically acceptable excipient in the form of a patch in the form of a single adhesive polymer layer in which the derivative 8-isoxazole-2-aminotetraline is distributed.
A matrix or reservoir pharmaceutical composition for topical administration of at least one derivative of 8-isoxazole-2-aminotetraline in a therapeutically effective amount, an anti-oxidizing agent and at least one pharmaceutically acceptable excipient in the form of a patch.
A matrix or reservoir pharmaceutical composition for topical administration of 8-isoaxazole-2-aminotetraline is 1,2,3,4-tetrahydro-8-(5-isoaxazolyl)-N,N-diisopropyl-2-naphthalenamine or one of its pharmaceutically acceptable salts in a therapeutically effective amount and of at least one of pharmaceutically excipient in the form of a patch.
A matrix or reservoir pharmaceutical composition for topical administration of at least one derivative of 8-isoxazole-2-aminotetraline in a therapeutically effective amount, a promoter of transdermal absorption and at least one pharmaceutically acceptable excipient in the form of a patch.
A method of treating irritable bowel syndrome in warm-blooded animals comprising transdermally administering to warm-blooded animals in need thereof a matrix or reservoir pharmaceutical composition for topical administration of at least one derivative of 8-isoxazole-2-aminotetraline in a therapeutically effective amount and at least one pharmaceutically acceptable excipient in the form of a patch.
Dependencies are inferred from the claim text.