Quinolone carboxylic acid compositions and related methods of treatment
AssigneesInsite Vision Incorporated, SSP Co., Ltd.
InventorsSamir Roy, Santosh Kumar Chandrasekaran, Katsumi Imamori, Takemitsu Asaoka, Akihiro Shibata, Masami Takahashi, Lyle M. Bowman
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Abstract
The present invention relates to the use of quinolone carboxylic acid formulations in the treatment of ocular and periocular infections. The present invention also relates to sustained release compositions comprising specific quinolone carboxylic acid compounds. The invention also relates to quinolone carboxylic acid compositions and methods of preparing the same.
Claims37
A topical ophthalmic broad spectrum antibiotic composition comprising:
- from about 0.005% to about 10% by weight, based upon the total weight of the composition, of a quinolone carboxylic acid derivative of formula (I),
- wherein R1 is a hydrogen atom, an alkyl group, an aralkyl group, an ester residual group which can be hydrolyzed in vivo, R2 is a hydrogen atom or an amino group which may be substituted by one or two lower alkyl groups, X is a hydrogen atom or a halogen atom, Y is CH2, O, S, SO, SO2, or N—R3, wherein R3 is a hydrogen atom or a lower alkyl group, and Z is an oxygen atom or two hydrogen atoms;
- and a carboxy containing polymer;
- wherein said topical ophthalmic broad spectrum antibiotic composition is nonirritating to ocular tissue.
A method of treating or preventing a bacterial infection in the ocular or periocular region comprising:
- delivering to the ocular or periocular region a topical ophthalmic broad spectrum antibiotic composition comprising from about 0.005% to about 10% by weight, based upon the total weight of the composition, of a quinolone carboxylic acid derivative of formula (I),
- wherein R1 is a hydrogen atom, an alkyl group, an aralkyl group, an ester residual group which can be hydrolyzed in vivo, R2 is a hydrogen atom or an amino group which may be substituted by one or two lower alkyl groups, X is a hydrogen atom or a halogen atom, Y is CH2, O, S, SO, SO2, or N—R3, wherein R3 is a hydrogen atom or a lower alkyl group, and Z is an oxygen atom or two hydrogen atoms;
- wherein said topical ophthalmic broad spectrum antibiotic composition is nonirritating to ocular tissue.
A method of preparing a sustained release topical ophthalmic delivery system, comprising:
- preparing a topical ophthalmic broad spectrum antibiotic composition comprising from about 0.005% to about 10% by weight, based upon the total weight of the composition, of a quinolone carboxylic acid derivative of formula (I),
- wherein R1 is a hydrogen atom, an alkyl group, an aralkyl group, an ester residual group which can be hydrolyzed in vivo, R2 is a hydrogen atom or an amino group which may be substituted by one or two lower alkyl groups, X is a hydrogen atom or a halogen atom, Y is CH2, O, S, SO, SO2, or N—R3, wherein R3 is a hydrogen atom or a lower alkyl group, and Z is an oxygen atom or two hydrogen atoms;
- and,
- packaging said composition for administration to the eye;
- wherein said topical ophthalmic broad spectrum antibiotic composition is nonirritating to ocular tissue.
Dependencies are inferred from the claim text.