Insecticidal combination to control mammal fleas, in particular fleas on cats and dogs
AssigneeMerial Limited
InventorPhilippe Jeannin
Life of this patent
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Abstract
Process and composition, in particular for controlling fleas on small mammals, characterized in that the composition includes, on the one hand, at least one insecticide of 1-N-arylpyrazole type, in particular fipronil, and, on the other hand, at least one compound of IGR (insect growth regulator) type, in doses and proportions which are parasiticidally effective on fleas, in a fluid vehicle which is acceptable for the animal and convenient for local application to the skin, preferably localized over a small surface area.
Claims36
A synergistic spot-on composition for the long lasting protection against ectoparasites on mammals which comprises synergistic amounts
- (A) at least one compound of the formula:
- in which:
- R1 is CN or methyl or a halogen atom;
- R2 is S(O)nR3 or 4,5-dicyanoimidazol-2-yl or haloalkyl;
- R3 is alkyl or haloalkyl;
- R4 represents a hydrogen or halogen atom;
- or a radical NR5R6, S(O)mR7, C(O)R7, C(O)O—R7, alkyl, haloalkyl, or OR8 or a radical —N═C(R9)(R10);
- R5 and R6 independently represent a hydrogen atom or an alkyl, haloalkyl, C(O)alkyl, alkoxycarbonyl or S(O)r—CF3 radical;
- R5 and R6 may together form a divalent alkylene radical which may be interrupted by one or two divalent hereto atoms or;
- R7 represents an alkyl or haloalkyl radical;
- R8 represents an alkyl or haloalkyl radical or a hydrogen atom;
- R9 represents an alkyl radical or a hydrogen atom;
- R10 represents a phenyl or heteroaryl group optionally substituted with one or more halogen atoms or one or more substituents selected from the group consisting of OH, —O-alkyl, S-alkyl, cyano or alkyl;
- R11 and R12 represent, independently of each other, hydrogen, halogen, CN or NO2;
- R13 represents a halogen atom or a haloalkyl, haloalkoxy, S(O)qCF3 or SF5 group;
- m, n, q and r represent, independently of each other, an integer equal to 0, 1 or 2;
- X represents a trivalent nitrogen atom or a radical C—R12, the other three valency positions of the carbon atom forming part of the aromatic ring;
- with the proviso that when R1 is methyl, then R3 is haloalkyl, R4 is NH2, R11 is Cl, R13 is CF3 and X is N;
- or R2 is 4,5-dicyanoimidazol-2-yl, R4 is Cl, R11, is Cl, R13 is CF3 and X is ═C—Cl;
- (B) at least one insect growth regulator (IGR) that mimics juvinile hormones;
- (C) imidacloprid;
- and
- a fluid vehicle comprising at least one customary spot-on formulation adjuvant.
The synergistic spot-on composition according to claim which comprises a compound of formula (I) wherein R13 is haloalkyl.
Dependencies are inferred from the claim text.