Methods and compositions useful for modulation of angiogenesis and vascular permeability using SRC or Yes tyrosine kinases
AssigneeThe Scripps Research Institute
InventorsDavid A. Cheresh, Brian Eliceiri
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Abstract
The present invention describes methods for modulating vascular permeability (VP) in tissues using Src or modified Src protein, Yes protein or modified Yes protein, or mixtures thereof, and nucleic acids capable of expression such proteins. In particular, the invention describes methods for inhibiting VP using an inactive Src or Yes protein or a mixture thereof, or nucleic acids encoding therefor, or for potentiating VP using an active, Src or Yes protein or a mixture thereof, or nucleic acids encoding therefor. Related compositions and articles of manufacture are also disclosed.
Claims16
A pharmaceutical composition comprising tyrosine kinase proteins Src and Yes, together with a pharmaceutically acceptable carrier wherein at least one of the Src protein and the Yes protein is an active kinase and at least one of the Src protein and the Yes protein is an inactive.
An article of manufacture comprising packaging material and a pharmaceutical composition contained within said packaging material, wherein said pharmaceutical composition is capable of modulating vascular permeability in a tissue suffering from a disease condition, wherein said packaging material comprises a label which indicates that said pharmaceutical composition can be used for treating disease conditions by modulating vascular permeability, and wherein said pharmaceutical composition comprises a tyrosine kinase Src protein and Yes protein, in a pharmaceutically acceptable carrier and at least one of the Src protein and the Yes protein is an active kinase and at least one of the Src protein and the Yes protein is an inactive kinase.
Dependencies are inferred from the claim text.