Suppressor cells induced by culture with mesenchymal stem cells for treatment of immune responses in transplantation
AssigneeOsiris Therapeutics, Inc.
InventorsKevin McIntosh, Elena Klyushnenkova
Life of this patent
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Abstract
A method of reducing an immune response to a transplant in a recipient by treating said recipient with an amount of suppressor T cells effective to reduce or inhibit host rejection of the transplant. The suppressor T cells can be administered before, at the same time as, or after the transplant. Also disclosed is a method of inducing a reduced immune response against a host by foreign tissue, i.e., graft versus host disease, by treatment with suppressor T cells.
Claims14
A method of reducing an immune response against an alloantigen, comprising:
- (a) culturing activated human T-cells with human mesenchymal stem cells in vitro, whereby said human mesenchymal stem cells induce said activated human T-cells to become human suppressor T-cells;
- and
- (b) contacting immune effector cells with said human suppressor T-cells in an amount effective to reduce the immune response.
A method of treating a transplant recipient for graft versus host disease, comprising:
- (a) culturing activated human T-cells with human mesenchymal stem cells in vitro, whereby said human mesenchymal stem cells induce said activated human T-cells to become human suppressor T-cells;
- and
- (b) treating the recipient of a donor transplant with said human suppressor T-cells in an amount effective to reduce an immune response against the recipient by the transplant.
A method of reducing an immune response to a donor transplant, comprising:
- (a) culturing activated human T-cells with human mesenchymal stem cells in vitro to produce human suppressor T-cells;
- and
- (b) administering to the recipient of the donor transplant said human suppressor T-cells in an amount effective to reduce an immune response in the recipient to the transplant.
Dependencies are inferred from the claim text.