Post-labeling stabilization of radiolabeled proteins and peptides
AssigneeRhomed Incorporated
InventorsPaul O. Zamora, Michael J. Marek
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Abstract
The subject invention relates to the use of ascorbic acid and derivatives thereof in stabilizing radiolabeled proteins and peptides against oxidation loss of radiolabel and autoradiolysis. Ascorbic acid is added after radiolabeling, including any required incubation period, but prior to patient administration.
Claims6
A method for stabilizing a diagnostic radionuclide composition comprising a protein radiolabeled by direct radiolabeling with 99mTc, said method comprising adding a stabilizer selected from the group consisting of ascorbic acid and water soluble salts, esters and mixtures thereof to said composition, wherein said stabilizer is present in an amount sufficient to inhibit oxidation loss and autoradiolysis of said radiolabeled protein, and wherein prior to addition of said stabilizer, said radiolabeled protein is present in a composition which is substantially free of said stabilizer.
Dependencies are inferred from the claim text.