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US 6,685,672 B1Granted
Multi-balloon drug delivery catheter for angiogenesis
AssigneeEdwards Lifesciences Corporation
InventorMichael Robert Forman
Life of this patent
Estimating the term…
Abstract
A catheter and a method for using the catheter for site specific delivery of agents to or collecting agents from biological spaces. The catheter includes inflatable balloons which when inflated in a target segment of a biological space, create closed agent delivery pockets for the delivery or collection of agents from a defined space.
Claims38
A catheter for delivering agents to a defined biological space in vivo comprising:
- a catheter shaft having a proximal end and a distal end;
- marker bands on said catheter shaft;
- a first balloon proximal to said catheter shaft distal end;
- a second balloon proximal to said first balloon;
- a third balloon located proximal to said second balloon;
- a first agent delivery segment on said catheter shaft between said first balloon and said second balloon;
- and
- a second agent delivery segment on said catheter shaft between said second balloon and said third balloon.
5 more elements
A catheter for delivering agents to a defined biological space in vivo comprising:
- a first catheter shaft having a first shaft distal tip and a first balloon proximal to said first shaft distal tip, said first catheter shaft further comprising an agent delivery segment proximal to said first balloon and having orifices therein;
- a cuff proximal to said agent delivery segment on said first catheter segment;
- and
- a second catheter shaft longitudinally movable with respect to said first catheter shaft, said second catheter shaft having a second shaft distal tip and a second balloon proximal to said second shaft distal tip.
1 more element
A method for delivering agents to a defined biological space having side branches comprising:
- (a) providing a catheter comprising:
- a catheter shaft having a proximal end and a distal end;
- a first balloon proximal to said catheter shaft distal end;
- a second balloon proximal to said first balloon and placed at a distance relative to said first balloon to correlate with the average or typical distance between the side branches;
- and
- a first agent delivery segment on said catheter shaft between said first balloon and said second balloon;
- (b) guiding said catheter shaft distal end to a proximal end of a target segment in vivo,
- (c) aligning said first and said second balloons in relation to the side branches to create a defined space within the target segment;
- (d) inflating said first and second balloons;
- (e) forming an agent delivery pocket in said defined space between said first and said second balloons;
- (f) infusing an agent into an agent delivery pocket via orifices in said agent delivery segment;
- (g) deflating said first and said second balloons;
- and
- (h) withdrawing said catheter from the biological space.
11 more elements
A method for delivering agents to a defined biological space having side branches comprising:
- (a) providing a catheter comprising:
- a catheter shaft having a proximal end and a distal end;
- a first balloon proximal to said catheter shaft distal end;
- a second balloon proximal to said first balloon;
- a third balloon located proximal to said second balloon;
- a first agent delivery segment on said catheter shaft between said first balloon and said second balloon;
- and
- a second agent delivery segment on said catheter shaft between said second balloon and said third balloon;
- (b) guiding said catheter shaft distal end to a proximal end of a target segment in vivo,
- (c) aligning two or more of said first, second and third balloons in relation to the side branches to create a defined space within the target segment;
- (d) inflating at least two of said first, second and third balloons;
- (e) forming at least one agent delivery pocket in said defined space between at least two of said first, second and third balloons;
- (f) infusing an agent into said at least one agent delivery pocket via orifices in at least said first or said second agent delivery segment;
- (g) deflating said at least two of said first, second and third balloons;
- and
- (h) withdrawing said catheter from the biological space.
13 more elements
A method for delivering agents to a defined biological space comprising:
- (a) providing a catheter comprising:
- a first catheter shaft having a first shaft distal tip, a first balloon proximal to said first shaft distal tip, and an agent delivery segment having orifices therein, proximal to said first balloon;
- and
- a second catheter shaft longitudinally movable with respect to said first catheter shaft, said second catheter shaft having a second shaft distal tip and a second balloon proximal to said second shaft distal tip;
- (b) guiding said first shaft distal tip to a proximal end of a first target segment in vivo;
- (c) aligning said first balloon in register with a side branch within the first target segment;
- (d) inflating said first balloon on the proximal end of said first shaft;
- (e) adjusting said second shaft longitudinally relative to said first shaft to position said second balloon at the distal end of the first target segment;
- (f) aligning said second balloon in register with a side branch within the first target segment;
- (g) inflating said second balloon to form a closed agent delivery pocket between said first balloon and said second balloon;
- (h) infusing an agent into the agent delivery pocket via said orifices in said agent delivery segment of said first shaft;
- (i) deflating said first and second balloons;
- and
- (j) withdrawig said catheter from the bioloical space.
11 more elements
A method for delivering agents to a target segment within a biological vessel comprising:
- (a) injecting contrast dye into the vessel in order to determine the location of side branches relative to the target segment of the vessel;
- (b) using said contrast dye to obtain images of side branch runoff;
- (c) inserting a balloon catheter having two or more balloons into the vessel;
- (d) keeping said balloons deflated and advancing said balloon catheter proximal to the vessel target segment;
- (e) adjusting said balloon catheter so that when said balloons are inflated the side branches are blocked;
- (f) inflating two or more of said balloons to create the target segment;
- and
- (g) injecting a therapeutic agent within the target segment.
5 more elements
A catheter for delivering agents to a blood vessel having side branches in vivo comprising:
- a catheter shaft having a proximal end and a distal end;
- a first balloon proximal to said catheter shaft distal end;
- a second balloon proximal to said first balloon;
- wherein the distance between said first balloon and said second balloon correlates with the average or typical distance between the blood vessel side branches;
- a third balloon located proximal to said second balloon;
- a first agent delivery segment on said catheter shaft between said first balloon and said second balloon;
- and
- a second agent delivery segment on said catheter shaft between said second balloon and said third balloon.
5 more elements
A catheter for delivering agents to a blood vessel having side branches in vivo comprising:
- a catheter shaft having a proximal end and a distal end;
- a first balloon proximal to said catheter shaft distal end;
- a second balloon proximal to said first balloon;
- a third balloon located proximal to said second balloon;
- wherein the distance between said second balloon and said third balloon correlates with the average or typical distance between the blood vessel side branches;
- a first agent delivery segment on said catheter shaft between said first balloon and said second balloon;
- and
- a second agent delivery segment on said catheter shaft between said second balloon and said third balloon.
5 more elements
A catheter for delivering agents to a blood vessel having side branches in vivo comprising:
- a catheter shaft having a proximal end and a distal end;
- a first balloon proximal to said catheter shaft distal end;
- a second balloon proximal to said first balloon;
- wherein the distance between said first balloon and said second balloon correlates with the average or typical distance between the blood vessel side branches;
- a third balloon located proximal to said second balloon;
- wherein the distance between said second balloon and said third balloon correlates with the average or typical distance between the blood vessel side branches;
- a first agent delivery segment on said catheter shaft between said first balloon and said second balloon;
- and
- a second agent delivery segment on said catheter shaft between said second balloon and said third balloon.
6 more elements
Dependencies are inferred from the claim text.