Methods for treating solid tumors using neutron therapy
AssigneeIsotron, Inc.
InventorsDavid Halpern, Steven K. Jacobs
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AssigneeIsotron, Inc.
InventorsDavid Halpern, Steven K. Jacobs
Estimating the term…
The invention described herein comprises a method of treating a subject having a disorder characterized by the presence of one or more tumors comprising inserting a miniaturized concentrated neutron emitting source into said tumor(s) for a time sufficient to irradiate the cells of the tumor(s). The invention method can be employed in the treatment of both malignant and non-malignant tumors and is especially useful in the treatment of malignant tumors found in the brain, prostate, and other internal organs. A preferred neutron source is californium-252. The majority of the tumor can be surgically removed prior to insertion of the neutron emitting source. In a further embodiment of the invention, a neutron capture compound can be localized to the cells of the tumor prior to insertion of the miniaturized neutron emitting source in order to augment the effects of neutron therapy.
A method of treating a subject having a disorder characterized by the presence of a tumor, the method comprising inserting one or more miniaturized concentrated neutron emitting source into the tumor using a closed-end catheter and maintaining the source in the tumor for a time sufficient to eradicate the tumor, wherein the neutron emitting source is shaped to substantially match a rounded shape of the closed-end catheter and has a diameter of no more than about 2 mm along an axis.
A method of treating a subject having a disorder characterized by the presence of a tumor, the method comprising surgically removing the majority of said tumor and subsequently using a close-ended catheter containing a miniaturized concentrated neutron emitting source to insert the neutron emitting source into the space previously occupied by the tumor for a time sufficient to eradicate any tumor cells not surgically removed, wherein the neutron emitting source is shaped to substantially match an end portion of the close-ended catheter and has a diameter of no more than about 2 mm along an axis.
Dependencies are inferred from the claim text.