Lyopohilization method
AssigneeBayer Aktiengesellschaft
InventorsBernd Sennhenn, Martin Kramer
Life of this patent
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Abstract
The invention relates to a lyophilization method which comprises the following steps: reducing the pressure in the drying chamber until the onset of a visible crystallization of the solvent at a temperature in the drying chamber which is above the solidification point of the preparation; reducing the temperature in the drying chamber to a temperature which is below the solidification point of the preparation or is identical to it, until completion of the crystallization of the solvent, resulting in a frozen solvent; and sublimation of the frozen solvent by means of reduced pressure.
Claims9
A method for freeze-drying a solvent-containing preparation in a drying chamber comprising the steps of cooling the preparation and crystallizing the solvent and sublimation of the resulting frozen solvent by means of reduced pressure, in which the method is carried out as follows:
- Phase 1:
- reducing the pressure in the drying chamber until the onset of a visible crystallization of the solvent at a temperature in the drying chamber which is above the solidification point of the preparation;
- Phase 2:
- reducing the temperature in the drying chamber to a temperature which is below the solidification point of the preparation or is identical to it, until completion of the crystallization of the solvent, resulting in frozen solvent;
- Phase 3:
- sublimation of the frozen solvent by means of reduced pressure.
Dependencies are inferred from the claim text.