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US 6,683,192 B2Granted
Small organic molecule regulators of cell proliferation
AssigneeCuris, Inc.
InventorsAnthony David Baxter, Edward Andrew Boyd, Oivin M. Guicherit, Jeffrey Porter, Stephen Price, Lee Rubin, John Harry Alexander Stibbard
Life of this patent
Estimating the term…
Abstract
A compound represented in general formula (X) and (XI):
Claims30
compound represented in general formula (X):
- wherein, as valence and stability permit,
- Ar represents a substituted or unsubstituted aryl or heteroaryl ring;
- X is selected from —C(═O)—, —C(═S)—, —S(O2)—, —S(O)—, and a methylene group optionally substituted with 1-2 lower alkyls;
- Y is absent for each occurrence;
- Z is absent or represents a substituted or unsubstituted aryl, carbocyclyl, heterocyclyl, or heteroaryl ring, or a lower alkyl, nitro, cyano, or halogen substituent;
- R represents, independently for each occurrence, H or substituted or unsubstituted lower alkyl;
- Cy′ represents a 3-chloro-benzo(b)thien-2-yl, 3-fluoro-benzo(b)thien-2-yl, or 3-methyl-benzo(b)thien-2-yl, wherein the benzo ring is substituted with from 1-4 substituents selected from halogen, nitro, cyano, methyl, and ethyl;
- M represents, independently for each occurrence, a substituted or unsubstituted methylene group, or two M taken together represent substituted or unsubstituted ethene or ethyne, wherein some or all occurrences of M in Mj form all or part of a cyclic structure;
- j represents an integer from 2 to 7;
- i represents 0 for all occurrences except in the sequence N—Mi—Y—Ar, where i represents 1;
- and k represents 0.
8 more elements
A compound represented in general formula (XI):
- wherein, as valence and stability permit,
- Ar represents a substituted or unsubstituted aryl or heteroaryl ring;
- X is selected from —C(═O)—, —C(═S)—, —S(O2)—, —S(O)—, and a methylene group optionally substituted with 1-2 lower alkyls;
- Y is absent for each occurrence;
- Z is absent or represents a substituted or unsubstituted aryl, carbocyclyl, heterocyclyl, or heteroaryl ring, or a lower alkyl, nitro, cyano, or halogen substituent;
- R represents, independently for each occurrence, H or substituted or unsubstituted lower alkyl;
- Cy′ represents a 3-chloro-benzo(b)thien-2-yl, 3-fluoro-benzo(b)thien-2-yl, or 3-methyl-benzo(b)thien-2-yl, wherein the benzo ring is substituted with from 1-4 substituents selected from halogen, nitro, cyano, methyl, and ethyl;
- M represents, independently for each occurrence, a substituted or unsubstituted methylene group, or two adjacent M taken together represent substituted or unsubstituted ethene or ethyne;
- Cy represents a substituted or unsubstituted aryl, heterocyclyl, heteroaryl, or cycloalkyl, including polycyclic groups;
- i represents 0 for all occurrences except in the sequence N—Mi—Y—Ar, where i represents 1;
- and
- k represents 0.
9 more elements
Dependencies are inferred from the claim text.