Transplants for myocardial scars
AssigneeGenzyme Corporation
InventorsDonald A. G. Mickle, Ren-Ke Li, Richard D. Weisel
Life of this patent
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Abstract
A method is provided for forming a graft in heart tissue which comprises the transplantation of cells chosen from cardiomyocytes, fibroblasts, smooth muscle cells, endothelial cells and skeletal myoblasts. The grafts are especially useful in treating scar tissue on the heart.
Claims12
A method of forming a stable cardiac graft in a mammal, said method comprising transplanting skeletal myoblasts and fibroblasts into scar tissue in said mammal's heart, wherein said transplanted skeletal myoblasts and fibroblasts survive in said scar tissue after transplantation and wherein said transplanted skeletal myoblasts and fibroblasts improve cardiac function in said mammal.
A method for improving cardiac function in a mammal with myocardial injury, comprising the step of transplanting skeletal myoblasts and fibroblasts into said mammal's heart, wherein said skeletal myoblasts and fibroblasts are transplanted into said mammal's heart after fibrotic tissue has formed in response to said injury, and wherein said transplanted skeletal myoblasts and fibroblasts form a stable cardiac graft in said mammal's heart.
A method for improving cardiac function in a mammal with heart damage due to acute myocardial injury, comprising the step of transplanting skeletal myoblasts and fibroblasts into said mammal's heart, wherein said skeletal myoblasts and fibroblasts are transplanted into said mannnal's heart after an inflammatory response to said acute myocardial injury has subsided and wherein said transplanted skeletal myoblasts and fibroblasts form a stable cardiac graft in said mammal's heart.
Dependencies are inferred from the claim text.