Methods for sterilizing biological materials by multiple rates
AssigneeClearant, Inc.
InventorsMartin MacPhee, William N. Drohan, Randall S. Kent, Tom Lynch, Glenn Calvert, Shirley Miekka, David Mann, Wilson Burgess
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Abstract
Methods are disclosed for sterilizing biological materials to reduce the level of one or more biological contaminants or pathogens therein, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, single or multicellular parasites, and/or prions or similar agents responsible, alone or in combination, for TSEs.
Claims224
A method for sterilizing fetal bovine serum comprising irradiating said fetal bovine serum with gamma radiation at ambient temperature or below at an effective dose rate for a period of time effective to sterilize said fetal bovine serum, wherein said effective dose rate is not constant and comprises a rate between 0.1 kGy/hr to 3.0 kGy/hr for at least a portion of said period of time and a rate of at least 6.0 kGy/hr for at least another portion of said period of time.
The method according to 5, wherein the total dose of gamma radiation is at least 25 kGy.
Dependencies are inferred from the claim text.