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US 6,680,047 B2Granted
Diagnostic/therapeutic agents
AssigneeAmersham Health AS
InventorsJo Klaveness, Pål Rongved, Anders Høgset, Helge Tolleshaug, Alan Cuthbertson, Aslak Godal, Lars Hoff, Geir Gogstad, Klaus Bryn, Anne Nævestad, Dagfinn Løvhaug, Halldis Hellebust, Magne Solbakken
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Abstract
Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.
Claims30
A combined formulation comprising:
- i) a first administrable composition comprising a first pre-targeting vector;
- and
- ii) a second administrable composition comprising a targetable diagnostic and/or therapeutically active agent, said agent comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said reporter further comprising a moiety having affinity for said pre-targeting vector and a second vector, the first and second vectors binding to different targets on the same or different cells.
Dependencies are inferred from the claim text.