Elongase genes and uses thereof
AssigneeAbbott Laboratories
InventorsPradip Mukerji, Amanda Eun-Yeong Leonard, Yung-Sheng Huang, Suzette L. Pereira
Life of this patent
Estimating the term…
Loading patent…
AssigneeAbbott Laboratories
InventorsPradip Mukerji, Amanda Eun-Yeong Leonard, Yung-Sheng Huang, Suzette L. Pereira
Estimating the term…
The subject invention relates to the identification of several genes involved in the elongation of polyunsaturated acids (i.e., “elongases”) and to uses thereof. At least two of these genes are also involved in the elongation of monounsaturated fatty acids. In particular, elongase is utilized in the conversion of gamma linolenic acid (GLA) to dihomogamma linolenic acid (DGLA) and in the conversion of AA to adrenic acid (ADA), or eicosapentaenoic acid (EPA) to ω3-docosapentaenoic acid (DPA). DGLA may be utilized in the production of polyunsaturated fatty acids, such as arachidonic acid (AA), docosahexaenoic acid (DHA), EPA, adrenic acid, ω6-docosapentaenoic acid or ω3-docosapentaenoic acid which may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.
An isolated nucleic acid sequence comprising or complementary to a nucleic acid sequence encoding a polypeptide having elongase activity, wherein the amino acid sequence of said polypeptide has at least 80% amino acid sequence identity to SEQ ID NO:7.
A method of producing an elongase enzyme comprising the steps of:
A vector comprising:
Dependencies are inferred from the claim text.