Isolated nucleic acid molecules encoding human pyruvate dehydrogenase E1-alpha subunit proteins
AssigneeApplera Corporation
InventorsFangcheng Gong, Karen A. Ketchum, Valentina DiFrancesco, Ellen M. Beasley
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Abstract
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the enzyme peptides, and methods of identifying modulators of the enzyme peptides.
Claims24
An isolated nucleic acid molecule consisting of a nucleotide sequence selected from the group consisting of:
- (a) a nucleotide sequence that encodes a polypeptide comprising the amino acid sequence of SEQ ID NO:2;
- (b) a nucleotide sequence consisting of SEQ ID NO:1;
- (c) a nucleotide sequence consisting of SEQ ID NO:3;
- and
- (d) a nucleotide sequence that is completely complementary to a nucleotide sequence of(a)-(c).
An isolated polynucleotide consisting of the nucleotide sequence of SEQ ID NO:1.
An isolated polynucleotide consisting of the nucleotide sequence of SEQ ID NO:3.
An isolated nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of:
- (a) a cDNA sequence that encodes SEQ ID NO:2;
- (b) SEQ ID NO:1;
- (c) nucleotides 90-1280 of SEQ ID NO:1;
- and
- (d) a nucleotide sequence that is completely complementary to a nucleotide sequence of (a)-(c).
An isolated nucleic acid molecule encoding a pyruvate dehydrogenase E1-alpha subunit, wherein the nucleic acid molecule consists of a nucleotide sequence selected from the group consisting of:
- (a) a nucleotide sequence that encodes an amino acid sequence having at least 99% sequence identity to SEQ ID NO:2;
- (b) a nucleotide sequence having at least 99% sequence identity to SEQ ID NO:1;
- and
- (c) a nucleotide sequence having at least 99% sequence identity to SEQ ID NO:3.
Dependencies are inferred from the claim text.