Tissue specific adenoviral vectors
AssigneeCell Genesys, Inc.
InventorsDaniel R. Henderson, Eric R. Schuur
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Abstract
Host cell specific adenovirus vehicles are provided for transfecting target host cells. By providing for transcriptional initiating regulation dependent upon transcription factors that are only active in specific, limited cell types, virus replication will be restricted to the target cells. The modified adenovirus may be used as a vehicle for introducing new genetic capability, particularly associated with cytotoxicity for treating neoplasia.
Claims31
A replication competent adenovirus vector comprising an adenovirus gene under transcriptional control of a prostate cell specific transcriptional response element (TRE).
An adenovirus vector comprising a first adenovirus gene under transcriptional control of a first prostate cell specific transcriptional response element (TRE) and a second gene under transcriptional control of a second prostate cell specific TRE.
A method for selective cytolysis of a prostate target cell the method comprising:
- contacting said target cell with an adenovirus vector comprising an adenovirus gene essential for replication under transcriptional control of a prostate cell specific transcriptional response element (TRE), wherein the prostate target cell allows the prostate cell-specific TRE to function
- wherein said adenovirus vector is propagated and causes lysis of said target prostate cell.
Dependencies are inferred from the claim text.