Multi-well plate with perimeteral heat reservoir
AssigneeAventis Pharmaceuticals Inc.
InventorsFahad A. D. Al-Obeidi, Richard E. Austin
Life of this patent
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Abstract
A multi-well plate is disclosed for holding chemical compounds for heating in a microwave oven. The plate is a substantially planar member having wells arranged in an array of rows and columns in its upper surface. The plate has heat reservoirs in the form of fluid filled channels or elongated solid bodies positioned lengthwise along the side portions of the plate to reduce temperature gradients among the wells across the length and width of the plate. The heat reservoirs prevent or mitigate heat loss from the wells near the side portions of the plate and ensure that the compounds in all of the wells have a uniform temperature.
Claims25
A multi-well plate for holding a compound for testing, said plate comprising:
- a substantially planar member bounded by downwardly depending side portions and having an upper surface;
- a plurality of wells positioned in said planar member and adapted to hold samples of said compound, each of said wells having an opening located on said upper surface, a first group of said wells being arranged adjacent to one of said side portions and a second group of said wells being arranged adjacent to another of said side portions;
- a first elongated chamber extending within said planar member lengthwise along said one side portion and confined between said one side portion and said first group of wells;
- a second elongated chamber extending within said planar member lengthwise along said other side portion and confined between said other side portion and said second group of wells, said first and second chambers being in fluid communication with one another, said first chamber being adapted to confine a fluid between said one side portion and said first group of wells, said second chamber being adapted to confine a fluid between said other side portion and said second group of wells, said fluid having the capacity to act as a heat reservoir and resist temperature changes of said samples in said first and second groups of wells relative to the samples in others of said wells.
A multi-well plate for holding a compound for testing, said plate comprising:
- a substantially planar member bounded by a plurality of downwardly depending side portions and having an upper surface;
- a plurality of wells positioned in said planar member and adapted to hold said samples of said compound, each of said wells having an opening located on said upper surface, a group of said wells being arranged adjacent to said side portions;
- an elongated chamber extending continuously around said planar member, said chamber being confined between said side portions and said wells adjacent to said side portions;
- and
- a fluid confined in said chamber between said side portions and said wells, said fluid having a capacity to act as a heat reservoir to resist temperature changes of said samples in said wells adjacent to said side portions relative to samples in others of said wells.
A multi-well plate for holding a compound for testing, said plate comprising:
- a substantially planar member having an upper surface and a plurality of side portions bounding said planar member;
- a plurality of wells positioned in said planar member and adapted to hold samples of said compound, each of said wells having an opening located on said upper surface, a first group of said wells being arranged adjacent to one of said side portions;
- and
- a first elongated body confined between said one side portion and said first group of said wells, said body comprising a solid material heatable by microwaves and having a capacity to act as a heat reservoir to resist temperature changes of said samples in said first group of wells relative to the samples in others of said wells.
A multi-well plate for holding a compound for testing, said plate comprising:
- a substantially planar member bounded by downwardly depending side portions and having an upper surface;
- a plurality of wells positioned in said planar member and adapted to hold samples of said compound, each of said wells having an opening located on said upper surface, a group of said wells being arranged adjacent to said side portions;
- and
- an elongated chamber extending continuously around said planar member and confined between said side portions and said wells positioned adjacent to said side portions, said chamber being adapted to confine a fluid between said portions and said wells, said fluid having the capacity to act as a heat reservoir and resist temperature changes of said samples in said group of wells positioned adjacent to said side portions relative to the samples in others of said wells.
Dependencies are inferred from the claim text.