Method and apparatus for high resolution ex-situ NMR spectroscopy

A method for two dimensional homonuclear correlation spectroscopy of a sample in an inhomogeneous static magnetic field, comprising:

• applying a sequence of pulses to a sample, said pulse sequence having at least one desensitization pulse, a plurality of excitation pulses and a plurality of z-rotation pulses;
• acquiring nuclear magnetic resonance data;
• and
• resolving and recording the data.

A method for heteronuclear correlation NMR spectroscopy of a sample in an inhomogeneous static magnetic field, comprising:

• applying a sequence of pulses to a sample, said pulse sequence having at least one desensitization pulse, a plurality of excitation pulses and a plurality of z-rotation pulses;
• acquiring nuclear magnetic resonance data;
• and
• resolving and recording the data.

A method for providing high resolution ex-situ NMR spectroscopy, comprising:

• subjecting a sample to an inhomogeneous static magnetic field;
• matching static field and radio frequency gradients in regions of the sample;
• sequentially exposing the sample to composite z-rotation variable inversion pulses;
• and
• obtaining chemical shift data from NMR signals.

A method for providing high resolution ex-situ NMR spectroscopy, comprising:

• subjecting a sample to an inhomogeneous static magnetic field;
• matching the static field and radio frequency gradients in regions of the sample;
• exposing said sample to at least one excitation pulse;
• sequentially exposing said sample to a plurality of full passage adiabatic pulses each providing a nutation echo;
• and
• acquiring nuclear magnetic resonance data.

A method for reducing residual line width due to static field inhomogeneities during high resolution in-situ NMR spectroscopy, comprising:

• shimming a superconducting NMR magnet having a sample within the bore of said magnet;
• matching static field and radio frequency gradients in the sample;
• sequentially exposing the sample to composite z-rotation pulses;
• and
• acquiring nuclear magnetic resonance data wherein said residual line width due to static field inhomogeneities is reduced.

An apparatus for conducting ex-situ nuclear magnetic resonance spectroscopy, comprising:

• a switchable coil;
• an antenna;
• a plurality of magnets configured to create a magnetic field gradient with a saddle point;
• and
• means for recording NMR spectral information.