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US 6,674,069 B1Granted
In-line reflecting time-of-flight mass spectrometer for molecular structural analysis using collision induced dissociation
AssigneeJeol USA, Inc.
InventorsCharles D. Martin, Gary L. Samuelson, Edward E. Owen, Jeffrey W. Finch
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Abstract
A tandem mass spectrometer apparatus includes an ion source (29); a first mass spectrometer MS-1 having a magnetic sector (24) and an electric sector (21); and a second mass spectrometer MS-2 having a CID cell (13), an offset parabolic ion mirror (17) and an ion detector (18).
Claims5
A tandem mass spectrometry method with collision induced dissociation comprising the steps for:
- a) using a first mass spectrometer to select precursor ions of a selected mass;
- b) forming a packet of precursor ions;
- c) focusing each packet of precursor ions;
- d) fragmenting the packet of focused precursor ions so as to form product ions;
- e) passing precursor and product ions into an offset parabolic ion mirror for providing time-of-flight dispersion among product ions of differing mass-to-charge ratios while maintaining near zero flight time dispersion among product ions of the same mass-to-charge ratios having large energy differences;
- and
- f) detecting the arrival times of the precursor and product ions.
4 more elements
A tandem mass spectrometry apparatus comprising:
- a) a first mass spectrometer for selecting precursor ions of a predefined mass;
- b) means for forming a packet of precursor ions;
- c) means for focusing each packet of precursor ions;
- d) means for fragmenting the precursor ions to form product ions;
- e) an offset parabolic field ion mirror for providing time-of-flight dispersion among product ions of differing mass-to-charge ratios while maintaining near zero flight time dispersion among product ions of the same mass-to-charge ratios having large energy differences;
- and
- f) means for detecting the arrival times of the precursor and product ions.
4 more elements
Dependencies are inferred from the claim text.