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AssigneeCalifornia Institute of Technology
InventorsPeter B. Dervan, Eldon E. Baird
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The design, synthesis, and use of cyclic compounds, including cyclic polyamides, is described. Such compounds comprise at least two polymer portions, one of which comprises at least three molecular units, and the other comprises at least four molecular units. At least one molecular unit of such a compound is a hydrogen bond donor or acceptor. The polymer portions are covalently linked to form a cycle. These compounds are capable of targeting specific nucleotide sequences in double-stranded nucleic acids, particularly double-stranded DNA. Accordingly, such compounds can be used to modulate, e.g., increase or decrease, the expression of one or more genes in vitro or in vivo.
A cyclic compound comprising from seven to twenty aromatic carboxamide units, one or more of which is a hydrogen bond donor or acceptor, which cyclic compound forms nucleotide base pair-specific interactions with a double-stranded nucleic acid molecule under physiological conditions, but excluding cyclo-(Im-Py-Im-Py-γ-Im-Py-Im-Py-(G-Dp)γ), cyclo(Im-Py-Im-Py-γ-Im-Py-Im-Py-(G-Dp)), and cyclo(Im-Py-Py-Py-γ-Im-Py-Py-Py-(G-Dp)), wherein Im is N-methylimidazole, Py is N-methylpyrrole, G is glycine, γ is γ-aminobutyric acid, and Dp is dimethylaminopropylamide.
A compound comprising a cyclic compound covalently associated with at least one second compound selected from the group consisting of a second cyclic compound, a protein, a nucleic acid, and a polyamide, wherein the cyclic compound comprises from seven to twenty aromatic carboxamide units, one or more of which is a hydrogen bond donor or acceptor, which cyclic compound forms nucleotide base pair-specific interactions with a double-stranded nucleic acid molecule under physiological conditions, but excluding cyclo(Im-Py-Im-Py-γ-Im-Py-Im-Py-(G-Dp)-γ), cyclo(Im-Py-Im-Py-γ-Im-Py-Im-Py-(G-Dp)), and cyclo(Im-Py-Py-Py-γ-Im-Py-Py-Py-(G-Dp)), and wherein Im is N-methylimidazole, Py is N-methylpyrrole, G is glycine, γ is γ-aminobutyric acid, and Dp is dimethylaminopropylamide.
A cyclic compound of from seven to 20 aromatic carboxamide units comprising a first polymer comprising at least three aromatic carboxamide units which are hydrogen bond donors, which first polymer is linked to a second polymer comprising at least four aromatic carboxamide units which are hydrogen bond donors, wherein the cyclic compound has a molecular structure that forms nucleotide base pair-specific interactions with a double-stranded nucleic acid molecule under physiological conditions.
A cyclic compound comprising:
Dependencies are inferred from the claim text.