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US 6,673,939 B2Granted
Process for the preparation of 1,2,4-triazolin-5-one derivatives
AssigneeMerck Sharp & Dohme Corp.
InventorCameron John Cowden
Life of this patent
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Abstract
The present invention relates to a process for the preparation of a compound of formula (I) wherein R represents hydrogen, C1-10alkyl, haloC1-10alkyl or aryl; which are useful intermediates in the preparation of morpholine derivatives of formula (A). Compounds of formula (A) are useful as therapeutic agents.
Claims10
A process for the preparation of a compound of formula (I)
- wherein
- R represents hydrogen, C1-10 alkyl, haloC1-10alkyl or aryl;
- which comprises:
- (i) reacting a triaryl- or trialkylorthoester of formula (II)
- wherein each R1 independently represents C1-10alkyl, or aryl, with a semicarbazide of formula (III)
- or a salt thereof, in an organic solvent;
- and
- (ii) collecting the resultant compound of formula (I).
5 more elements
Dependencies are inferred from the claim text.