Farnesyl transferase inhibitors
AssigneeSociete de Conseils de Recherches et d'Applications Scientifiques
InventorsThomas D. Gordon, Barry A. Morgan
Life of this patent
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Abstract
The present invention is directed to compounds of the wherein the variables are as defined in the specification. The compounds are useful for inhibiting farnesyl transferase and for the treatment of tumors and restenosis.
Claims4
A compound having the formula (I):
- wherein:
- R1 is H;
- R2 is H;
- R3 is H;
- R4 is H2 or O;
- R6 is phenyl, 1-naphthyl, or phenyl substituted with halo, lower alkyl or lower alkoxy;
- R5 is lower alkyl, cycloalkyl, or cycloalkyl lower alkyl;
- R7 is H;
- R8 is H;
- R9 is H;
- or a pharmaceutically acceptable salt thereof.
A compound having the formula (I):
- wherein:
- R1 is H;
- R2 is H;
- R3 is H;
- R4 is H2 or O;
- R6 is H;
- R7 is phenyl, 1-naphthyl, or phenyl substituted or unsubstituted with halo, lower alkyl, or lower alkoxy;
- R5 is lower alkyl, cycloalkyl, or cycloalkyl lower alkyl;
- R8 is H;
- R9 is H;
- or a pharmaceutically acceptable salt thereof.
A compound having the formula (I):
- wherein:
- R1 is H;
- R2 is H;
- R3 is H;
- R4 is H2 or O;
- R5 is lower alkyl, cycloalkyl, or cycloalkyl lower alkyl;
- R6 is phenyl, naphthyl, or phenyl substituted with halo, lower alkyl, or lower alkoxy;
- R7 is halo, phenyl, 1-naphthyl, or phenyl substituted with halo, lower alkyl, or lower alkoxy;
- R8 is H;
- R9 is H;
- or a pharmaceutically acceptable salt thereof.
A compound of the formula S-(dimethylethyl)-S′-[2-amino-3-oxo-3(8-butyl-2-(2-methoxy-phenyl)-5,6,7,8-tetrahydroimidazo[1,2a]pyrazin-7-yl) propyl]disulfide, [S-[2-amino-3-oxo-3-(8-cyclohexylmethyl)-2-(2-methoxyphenyl)-5,6,7,8-tetrahydro-imidazo[1,2a]pyrazin-7-yl)-propyl]-S′-cyclohexyl]disulfide or [S-[2-amino-3-oxo-3-(8-cyclohexylmethyl)-2-(2-methoxyphenyl)-5,6,7,8-tetrahydro-imidazo[1,2a]pyrazin-7-yl)-propyl]-S′-ethyl]disulfide.
Dependencies are inferred from the claim text.