Method of producing thiobarbituric acid derivatives
AssigneeSyngenta Crop Protection AG
InventorsBernhard Urwyler, Thomas Rapold, Marco Passafaro
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Abstract
Method of producing thiobarbituric acid derivatives of formula I wherein R1 is SH, S−M+ or CH3S—, and M+ is an alkali metal ion, by hydrogenolysis of a compound of formula II wherein R2 is chlorine or CH3O—, with a) a hydrogenolysis agent in the presence of an inert solvent and by a direct reaction of the hydrogenolysis product with an alkali metal methylate in methanol, or b) with a hydrogenolysis agent in the presence of an inert solvent and in the presence of a methylation reagent, and subsequently with an alkali metal methylate in methanol, as well as the use of these compound of formula I in the production of 7-[(4,6-dimethoxy-pyrimidin-2-yl)thio]-3-methylphthalide.
Claims13
Method of producing thiobarbituric acid derivatives of formula I
- wherein
- R1 is SH, S−M+ or CH3S—, and M+ is an alkali metal ion, by hydrogenolysis of a compound of formula II
- wherein R2 is chlorine or CH3O—, with
- a) a hydrogenolysis agent in the presence of an inert solvent and by a direct reaction of the hydrogenolysis product with an alkali metal methylate in methanol, or
- b) with a hydrogenolysis agent in the presence of an inert solvent and in the presence of a methylation reagent, and subsequently with an alkali metal methylate in methanol;
- wherein, hydrogenolysis according to variant a) or b) is carried out at a reaction temperature of 0° to 60° C.
Dependencies are inferred from the claim text.