Human tumor-associated gene
AssigneeJohn Wayne Cancer Institute
InventorDavid S. B. Hoon
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Abstract
The present invention describes a novel tumor marker antigen encoded by a gene designated as HOJ-1 (SEQ ID NO:1). In specific embodiment, the nucleic acid sequences disclosed herein are for used in the diagnosis and prognosis of cancer. Also provided are related protein and antibody compositions and various methods of use thereof, including methods for cancer diagnosis and treatment.
Claims20
An isolated DNA segment that encodes a HOJ-1 polypeptide comprising the amino acid sequence of SEQ ID NO:2.
An isolated recombinant host cell comprising an isolated DNA segment that comprises a DNA segment that encodes a HOJ-1 protein comprising the amino acid sequence of SEQ ID NO:2.
An isolated nucleic acid segment or 14 to no more than 100 contiguous nucleotides from bases 1-868 of SEQ ID NO:1, or the fill complement thereof, wherein the complement is a contiguous segment of 14 to no more than 100 nucleotides.
A composition of matter comprising a DNA segment that encodes a HOJ-1 polypeptide comprising the amino acid sequence of SEQ ID NO:2 packaged in a virus particle.
A composition of matter comprising a DNA segment that encodes a HOJ-1 polypeptide comprising the amino acid sequence of SEQ ID NO:2 packaged in a liposome.
Dependencies are inferred from the claim text.