Inhibitors of NF-κB Activation
AssigneeVlaams Interuniversitair Instituut Voor Biotechnologie VZW
InventorsRudi Beyaert, Karen Heyninck, Walter Fiers
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Abstract
The present invention relates to novel inhibitors of the Nuclear factor kappa B (NF-κB) activating pathway useful in the treatment of NF-κB related diseases and/or in the improvement of anti-tumor treatments. These inhibitors interfere early in the TRAF induced signaling pathway and are therefore more specific than IκB.
Claims6
An isolated protein capable of interacting with the protein A20 and inhibiting NF-κB activation, said isolated protein comprising an amino acid sequence as depicted in SEQ ID NO:
- 2.
An isolated protein capable of interacting with the protein A20 inhibiting NF-κB activation, said isolated protein comprising an amino acid sequence as depicted in SEQ ID NO:
- 3.
An isolated protein comprising the amino acid sequence depicted in SEQ ID NO:
- 9 said isolated protein having NF-κB inhibitory activity as determined by an NF-κB dependent reporter gene assay.
Dependencies are inferred from the claim text.