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US 6,673,891 B2Granted
Polymers for delivering nitric oxide in vivo
AssigneeDuke University
InventorsJonathan S. Stamler, Eric J. Toone, Richard S. Stack
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AssigneeDuke University
InventorsJonathan S. Stamler, Eric J. Toone, Richard S. Stack
Estimating the term…
Disclosed are novel polymers derivatized with at least one —SNO group per 1200 atomic mass unit of the polymer. In one embodiment, the S-nitrosylated polymer has stabilized —S-nitrosyl groups. In another embodiment the S-nitrosylated polymer prepared by polymerizing a compound represented by the following structural formula: R is an organic radical. Each X′ is an independently chosen aliphatic group or substituted aliphatic group. Preferably, each X′ is the same and is a C2-C6 alkylene group, more preferably —CH2—, —CH2CH2—, —CH2CH2CH2— or —CH2CH2CH2CH2—. p and m are independently a positive integer such that p+m is greater than two. The polymers of the present invention can be used to coat medical devices to deliver nitric oxide in vivo to treatment sites.
A polymer derivatized with at least one —SNOx, —ONOx, —NRNOx, —CH2NOx, —N(OH)—NOx, —CO—NR—NOx, —NHC(NH2)═N—NOx, ═N—NR—NOx, ═N—NOx, >N—NOx, C-nitro or C-nitroso group per 1200 atomic mass units of the polymer, wherein R is H, alkyl or substituted alkyl and x is 1 or 2.
A medical device for delivering nitric oxide to a treatment site in an individual or animal, wherein said medical device is suitable for implantation at the treatment in the individual or animal and which is coated with a polymer derivatized with at least one —SNOx, —ONOx, —NRNOx, —CH2NOx, —N(OH)—NOx, —CO—NR—NOx, —NHC(NH2)═N—NOx, ═N—NR—NOx, ═N—NOx, >N—NOx, C-nitro or C-nitroso group per 1200 atomic mass units of the polymer, wherein R is H, alkyl or substituted alkyl and x is 1 or 2.
A method of delivering nitric oxide to a treatment site or bodily fluid in an individual or animal, comprising the steps of:
Dependencies are inferred from the claim text.