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US 6,673,841 B2Granted
Alprostadil alkyl ester-containing composition for external application
AssigneeWhan In Pharm Co., Ltd.
InventorsDong Soo Lee, Kye Kwan Lee, Yun Seok Rhee, Jun Hee Jang, Sun Oh Jeoung, Sang Jin Kim, Sang Cheol Chi
Life of this patent
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Abstract
The present invention relates to a composition of topical preparation containing alprostadil alkyl ester, and more particularly, comprising an alprostadil alkyl ester, an oily vehicle, a skin permeation enhancer and an anti-irritant agent.
Claims8
A topical composition consisting of:
- (i) an alprostadil alkyl ester with alkyl having 1-5 carbon atoms in the range of 0.1-5% by weight;
- (ii) a non-aqueous oily vehicle in the range of 20-80% by weight, which is selected from the group consisting of mono or triglyceride of fatty acids and their polyethylene glycol complex, polyethylene glycol esters of vegetable oils, propylene glycol esters of fatty acids and a mixture of them;
- (iii) a pyrrolidone derivative in the range of 5-70% by weight as a skin permeation enhancer and an auxiliary skin permeation enhancer in the range of 1-30% by weight;
- (iv) an anti-irritant agent in the range of 1-30% by weight and
- (v) a thickener in the range of 1-50% by weight.
2 more elements
A topical composition consisting of:
- (i) an alprostadil alkyl ester with alkyl having 1-5 carbon atoms in the range of 0.1-5% by weight;
- (ii) a non-aqueous oily vehicle in the range of 20-80% by weight, which is selected from the group consisting of mono or triglyceride of fatty acids and their polyethylene glycol complex, polyethylene glycol esters of vegetable oils, propylene glycol esters of fatty acids and a mixture of them;
- (iii) a pyrrolidone derivative in the range of 5-70% by weight as a skin permeation enhancer;
- (iv) an anti-irritant agent in the range of 1-30% by weight and
- (v) a thickener in the range of 1-50% by weight.
2 more elements
Dependencies are inferred from the claim text.