Combination therapy for reducing the risks associated with cardiovascular disease
AssigneeMerck & Co., Inc.
InventorJonathan A. Tobert
Life of this patent
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Abstract
The instant invention provides methods for preventing or reducing the risk of developing atherosclerosis, as well as for halting or slowing the progression of atherosclerotic disease once it has become clinically evident, comprising the administration of a therapeutically effective amount of an HMG-CoA RI in combination with folic acid or a pharmaceutically acceptable salt or ester thereof to a person who is at risk of developing atherosclerosis or who already has atherosclerotic disease.
Claims29
A method for preventing or reducing the risk of developing atherosclerotic disease comprising the administration of a therapeutically effective amount of an HMG-CoA reductase inhibitor in combination with folic acid or a pharmaceutically acceptable salt or ester thereof to a person at risk of developing atherosclerotic disease.
A method for halting or slowing the progression of atherosclerotic disease comprising the administration of a therapeutically effective amount of an HMG-CoA reductase inhibitor in combination with folic acid or a pharmaceutically acceptable salt or ester thereof to a person who has atherosclerotic disease.
A method for preventing or reducing the risk of occurrence, or recurrence where the potential exists, of an atherosclerotic disease event comprising the administration of a therapeutically effective amount of an HMG-CoA reductase inhibitor in combination with folic acid or a pharmaceutically acceptable salt or ester thereof to a person at risk of having an atherosclerotic disease event.
A pharmaceutical composition comprising a therapeutically effective amount of an HMG-CoA reductase inhibitor, a therapeutically effective amount of folic acid or a pharmaceutically acceptable salt or ester thereof, and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.