Methods of treating fungal infections with inhibitors of NAD synthetase enzyme
AssigneeThe UAB Research Foundation
InventorsWayne J. Brouillette, Christie G. Brouillette, Lawrence J. DeLucas
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Abstract
The present invention provides methods of treating or preventing fungal infections in a host comprising administering a treatment effective or treatment effective amount of a yeast NAD synthetase inhibitor compound. The invention further provides a method of killing yeast comprising administering a yeast NAD synthetase compound that selectively binds to catalytic sites in yeast whereby the yeast is killed.
Claims87
A method of treating or preventing a fungal infection in a host comprising administering to a host a treatment or prevention effective amount of a yeast NAD synthetase enzyme inhibitor compound, wherein the prevention is used in a host in need of such treatment or a host susceptible to fungal infections.
A method of killing an yeast or decreasing the growth of an yeast, comprising contacting the yeast with an amount of a yeast NAD synthetase enzyme inhibitor effective to reduce or eliminate the production of NAD whereby the yeast is killed or the yeast growth is decreased.
A method of treating or preventing a fungal infection in a host comprising administering to a host a treatment or prevention effective amount of a compound of Structure 2, wherein the prevention is used in a host in need of such treatment or a host susceptible to fungal infections:
- wherein n is an integer of from 1 to 12, R1-R7 each, independently, is H, an unsubstituted or a substituted cyclic or aliphatic group, or a branched or an unbranched group, and wherein
- the linker is a cyclic or aliphatic, branched or an unbranched alkyl, alkenyl or an alkynyl group and wherein the linker may also contain one or more heteroatoms.
A method of killing a yeast or decreasing the growth of a yeast, comprising contacting the yeast with an amount of a compound of Structure 2 effective to reduce or eliminate the production of NAD whereby the yeast is killed or the yeast growth is decreased,
- wherein structure is
- wherein n is an integer of from 1 to 12, R1-R7 each, independently, is an H, an unsubstituted or a substituted cyclic or aliphatic group, or a branched or an unbranched group, and wherein the linker is a cyclic or aliphatic, branched or an unbranched alkyl, alkenyl, or an alkynyl group and wherein the linker may also contain heteroatoms.
Dependencies are inferred from the claim text.