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US 6,673,821 B2Granted
Nitrogen heterocycle inhibitors of aspartyl protease
AssigneeEnanta Pharmaceuticals, Inc.
InventorsGuoqiang Wang, Yat Sun Or, John Rougas, Steven Wayne Riesinger
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Abstract
Nitrogen heterocycles that inhibit aspartyl protease are disclosed, as are methods of treating diseases, particularly HIV, using these compounds. The compounds have the formula: A representative example is:
Claims4
A compound of the formula:
- wherein:
- R1 is chosen from the group consisting of C1-C20 alkyl, aryl, alkylaryl, substituted alkylaryl, C1-C10 alkoxy, C1-C10 oxaalkyl, aryloxy, substituted aryl, substituted aryloxy, heterocyclyl and heterocyclyloxy;
- R2 is chosen from the group consisting of C1-C10 hydrocarbon, substituted aryl and heterocyclyl;
- A is chosen from the group consisting of a direct bond, —SO2—, NHSO2—,
- is thiazolidine;
- R5, R6 and R7 are chosen from the group consisting of hydrogen and lower alkyl;
- D is —SO2—;
- and
- E is chosen from the group consisting of C1-C10 hydrocarbon, substituted aryl, heterocyclyl and substituted heterocyclyl.
6 more elements
Dependencies are inferred from the claim text.