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US 6,673,819 B2Granted
Compounds useful as antibacterial agents
AssigneeAstraZeneca AB
InventorsRolf Bergman, Arne Eek, Lars-Inge Olsson, Per Lindberg
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AssigneeAstraZeneca AB
InventorsRolf Bergman, Arne Eek, Lars-Inge Olsson, Per Lindberg
Estimating the term…
The present invention relates to novel compounds of Formula I, and pharmaceutically acceptable salts thereof, as antibacterial agents. The compounds of the present invention are nitric oxide releasing derivatives of proton pump inhibitors (NO-releasing PPIs). In further aspects, the invention relates to compounds of the invention for use in therapy; to processes for preparation of such new compounds; to pharmaceutical compositions containing at least one compound of the invention, or a pharmaceutically acceptable salt thereof, as active ingredient; and to the use of the active compounds in the manufacture of medicaments for the medical use indicated above. The invention also relates to new intermediates for use in the preparation of the novel compounds. Additionally the present invention relates to co-administration of NO-releasing PPIs with other known medicaments.
An isomer mixture consisting of a 5-methoxy isomer and a 6-methoxy isomer of a compound of formula I or a pharmaceutically acceptable salt or enantiomer thereof
A pharmaceutical formulation comprising the isomer mixture according to any one of claims 1-3, 6 or 7 as active ingredient in combination with a pharmaceutically acceptable diluent or carrier.
A method for the treatment or prophylaxis of conditions involving infection by Helicobacter pylori, which comprises administering to a mammal in need of such treatment an effective amount of the isomer mixture according to any one of claims 1-3, 6 or 7.
Dependencies are inferred from the claim text.