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US 6,673,814 B2Granted
Delivery systems and methods for noscapine and noscapine derivatives, useful as anticancer agents
AssigneeEmory University
InventorsHarish C. Joshi, Keqiang Ye, Judith Kapp, Jaren Landen, David Archer, Cheryl Armstrong, Fuqiang Liu
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Abstract
The present invention relates to methods useful for the treatment of neoplastic diseases, tumor cells, and the treatment of cancer delivering compounds of the formula The invention provides various methods of delivering such compounds, combinations of treatments, and altering such compounds to enhance their effectiveness.
Claims21
A delivery system for the treatment of neoplastic diseases, comprising a composition comprising a compound of the formula
- wherein
- A is
- and W is C1-6 alkyl;
- or
- and forms a six membered ring
- with B, said ring containing one nitrogen;
- Y is
- (a) C1-6 alkyl, or H;
- (b) C(O)—C1-6 alkyl;
- wherein Z is C1-6 alkyl or O—C1-6 alkyl;
- (d) aryl;
- or
- (e) heterocycle;
- B is a single bond, OH or halo;
- C is —OH, —CH2—, —O—, or forms a 5-membered lactone or lactam ring with D;
- and
- D is:
- (i) —OH, —CH2-halo, —CH(O), —COOH, —C(O)—O—C1-6 alkyl, —(CH2)n—, —CHOH—, wherein n is an integer and is 1, 2, or 3;
- or
- (ii) forms a 5-membered lactone or lactam ring with C;
- E is —H or —CH3;
- and
- F is —OH or —OCH3,
- or pharmaceutically acceptable salts thereof, and a controlled-release mechanism for providing prolonged delivery of the composition, whereby the delivery system enhances the delivery of the composition to a patient in need thereof.
21 more elements
A method for the treatment of neoplastic diseases, comprising:
- (a) administering to a mammal in need of such treatment an effective amount of a composition comprising a compound of the formula
- wherein:
- A is
- and W is C1-6 alkyl;
- or
- and forms a six membered ring
- with B, said ring containing one nitrogen;
- Y is
- (a) C1-6 alkyl, or H;
- (b) C(O)—C1-6 alkyl;
- wherein Z is C1-6 alkyl or O—C1-6 alkyl;
- (d) aryl;
- or
- (e) heterocycle;
- B is a single bond, OH or halo;
- C is —OH, —CH2—, —O—, or forms a 5-membered lactone or lactam ring with D;
- and
- D is:
- (i) —OH, —CH2-halo, —CH(O), —COOH, —C(O)—O—C1-6 alkyl, —(CH2)n—, —CHOH—, wherein n is an integer and is 1, 2, or 3;
- or
- (ii) forms a 5-membered lactone or lactam ring with C;
- E is —H or —CH3;
- and
- F is —OH or —OCH3,
- or pharmaceutically acceptable salts thereof, in combination with one or more of radiation therapy, phototherapy, surgical resection, immunotherapy, vaccination, interferon treatment, or stereotactic surgery for the treatment or prevention of tumors.
22 more elements
Dependencies are inferred from the claim text.