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US 6,673,808 B1Granted
Medicinal compositions
AssigneeFujisawa Pharmaceutical Co., Ltd.
InventorsRinta Ibuki, Fumio Shimojo, Satoshi Ueda, Toshihiko Toyoda, Masayuki Yamanaka, Erika Yoshida
Life of this patent
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Abstract
To provide a pharmaceutical composition comprising a macrolide compound, such as tricyclic compound (I) or its pharmaceutically acceptable salt, a dissolution/absorption promoter, a pharmaceutical base, and optionally a compatibilizing agent and/or a thickener. It is satisfactory in stability and absorption kinetics and/or a low irritation potential.
Claims6
A pharmaceutical composition, which is consisting essentially of a tricyclic compound, a dissolution/absorption promoter, a pharmaceutical base, a compatibilizing agent and a thickener,
- wherein said tricyclic compound is 17-allyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-22.3.1.04,9]octacos-18-ene-2,3,10,16-tetraone or its hydrate;
- the dissolution/absorption promoter is diethyl sebacate;
- the pharmaceutical base is a hydrophilic glycol;
- the compatibilizing agent is diethylene glycol monoethyl ether;
- and the thickener is cellulose polymer or carboxyvinyl polymer.
2 more elements
Dependencies are inferred from the claim text.