Cyanophenyl derivative

A cyanophenyl compound represented by the following formula (I) or a salt thereof

• wherein each symbol has the following meaning,
• R:
• cyano or nitro group,
• R1:
• a halogen atom or a cyano, halogeno-lower alkyl, nitro, carboxyl, lower alkyl, R6—A—, R7—S(O)p—, lower alkyl-C(═O)— or lower alkyl-O—C(═O)— group,
• R2 and R3:
• these may be the same or different from one another and each means a lower alkyl group, a carbamoyl group which may be substituted by 1 or 2 lower alkyl groups, or a lower alkyl-C(═O)— or lower alkyl-O—C(═O)— group, wherein R2 and R3 bind to optional carbon atoms on the ring,
• R4:
• this may be the same or different from one another and each means a hydrogen atom, a lower alkyl group, a carbamoyl group which may be substituted by 1 or 2 lower alkyl groups or a lower alkyl-C(═O)— or lower alkyl-O—C(═O)-group, wherein R2 and R3 bind to optional carbon atoms on the ring,
• R5:
• a lower alkyl;
• aryl-lower alkyl-O—;
• carboxyl;
• lower alkyl-O—C(═O)—;
• amido which may be substituted by 1 or 2 lower alkyl groups;
• an aryl, a monocyclic or bicyclic five or six-membered heterocycle containing from 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur, or cycloalkyl group each of the aryl, heterocycle and cycloalkyl is unsubstituted or substituted with 1 to 3 substitutents each selected from the group consisting of a halogen atom, halogeno-lower alkyl, lower alkyl, lower alkyl-O—, lower alkyl-S—, lower alkyl —S(O)—, lower alkyl-S(O)2—, sulfamoyl which may be substituted by 1 or 2 lower alkyl groups, halogeno-lower alkyl-O—, cyano, nitro, oxo(═O), lower alkyl-C(═O)—, aryl-C(═O)—, amino which may be substituted by 1 or 2 of lower alkyl or lower alkyl-C(═O)— or lower alkyl-O—C(═O)—, aryl-O—, amino-O—, carbamoyl which may be substituted by 1 or 2 lower alkyl, or carboxyl or lower alkyl-O—C(═O)—, a monocyclic or bicyclic five or six-membered heterocycle containing from 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur, and OH group(s);
• or N(R13)R14-lower alkyl-O—;
• with the proviso that when m=1, R4 and R5 may together form a five- or six-membered heterocycle which may have other hetero atoms,
• R6:
• a halogeno-lower alkyl;
• aryl;
• or lower alkyl which may be substituted by N(R9)R10, OH or lower alkyl-O—,
• R7:
• a lower alkyl, aryl or N(R11)R12
• R8, R9, R10, R11, R12, R13 and R14:
• hydrogen, lower alkyl or aryl, with the proviso that R6 and R8, R9 and R10 or R13 and R14 may together form a nitrogen-containing cycloalkyl which may have other hetero atoms and which is unsubstituted or substituted with 1 to 3 substituents each selected from the group consisting of a halogen atom, halogeno-lower alkyl, lower alkyl, lower alkyl-O—, lower alkyl-S—, lower alkyl-S(O)—, lower alkyl-S(O)2—, sulfamoyl which may be substituted by 1 or 2 lower alkyl groups, halogeno-lower alkyl-O—, cyano, nitro, oxo(═O), lower alkyl-C(═O)—, aryl-C(═O)—, amino which may be substituted by 1 or 2 of lower alkyl or lower alkyl-C(═O)— or lower alkyl-O—C(═O)—, aryl-O—, amino-O—, carbamoyl which may be substituted by 1 or 2 lower alkyl, or carboxyl or lower alkyl-O—C(═O)—, a monocyclic or bicyclic five or six-membered heterocycle containing from 1 to 4 hetero atoms selected from a nitrogen atom, an oxygen atom and sulfur atom which is unsubstituted or substituted with 1 to 2 substitutents each selected from the group consisting of an oxo group, a lower alkyl group, alkyl group, and an OH group,
• k:
• 2,
• n:1,
• m:
• 0 or 1,
• p:
• 0, 1 or 2,
• A:
• an oxygen atom or NR8,
• X:
• —C(═O)— group,
• Y:
• a bond, lower alkylene, —C(═O)— or —S(O)2— group,
• with the proviso that, when R5 is a lower alkyl group, Y is a group other than lower alkylene, and Z1 or Z2:
• CH.