2-pyridinylguanidine urokinase inhibitors

A compound of formula

• selected from:
• said compound wherein R1 is Cl, R2 is H, and R3 is H;
• said compound wherein R1 is Br, R2 is H, and R3 is H;
• said compound wherein R1 is H, R2 is Ph, and R3 is H;
• said compound wherein R1 is H, R2 is CONHCH2Ph, and R3 is H;
• said compound wherein R1 is Cl, R2 is H, and R3 is Cl;
• said compound wherein R1 is Cl, R2 is H, and R3 is Br;
• said compound wherein R1 is Br, R2 is H, and R3 is Cl;
• said compound wherein R1 is Cl, R2 is H, and R3 is E—CH═CHCO2H;
• said compound wherein R1 is Cl, R2 is H, and R3 is CH2CH2CO2H;
• said compound wherein R1 is Cl, R2 is H, and R3 is E—CH═CHCONHMe;
• said compound wherein R1 is Cl, R2 is H, and R3 is E—CH═CHCONHCH2Ph;
• said compound wherein R1 is Cl, R2 is H, and R3 is E—CH═CHCO-(3-hydroxypiperidino);
• said compound wherein R1 is Cl, R2 is H, and R3 is E—CH═CHCON(Me)CH2Ph;
• said compound wherein R1 is Cl, R2 is H, and R3 is E—CH═CHCO(morpholino);
• said compound wherein R1 is Cl, R2 is H, and R3 is E—CH═CHSO2NHMe;
• said compound wherein R1 is Cl, R2 is H, and R3 is E—CH═CHPh;
• said compound wherein R1 is Cl, R2 is H, and R3 is E—CH═CH(4-MeOC6H4);
• said compound wherein R1 is Cl, R2 is H, and R3 is E—CH═CH2(2-pyridyl);
• said compound wherein R1 is Cl, R2 is H, and R3 is E—CH═CH-cyclohexyl;
• said compound wherein R1 is Cl, R2 is H, and R3 is E—CH═CH-(3,4-methylenedioxyphenyl);
• said compound wherein R1 is Cl, R2 is H, and R3 is E—CH═CH(3-CN—C6H4);
• said compound wherein R1 is Cl, R2 is H, and R3 is C≡CPh;
• said compound wherein R1 is Cl, R2 is H, and R3 is OPh;
• said compound wherein R1 is Cl, R2 is H, and R3 is OCH2Ph;
• said compound wherein R1 is Cl, R2 is H, and R3 is OCH2CH2OH;
• said compound wherein R1 is Cl, R2 is H, and R3 is OCH2CH2OMe;
• said compound wherein R1 is Cl, R2 is H, and R3 is OCH2CONHCH2Ph;
• said compound wherein R1 is Cl, R2 is H, and R3 is OCH2(3-CO2Me—C6H4);
• said compound wherein R1 is Cl, R2 is H, and R3 is CH2OPh;
• said compound wherein R1 is Cl, R2 is Cl, and R3 is Cl;
• said compound wherein R1 is Cl, R2 is Me, and R3 is Cl;
• said compound wherein R1 is Cl, R2 is CH2OPh, and R3 is Cl;
• said compound wherein R1 is Cl, R2 is CH2NMeBn, and R3 is Cl;
• and
• said compound wherein R1 is Cl, R2 is CH2N(CH2)4, and R3 is Cl;
• or
• a pharmaceutically acceptable salt thereof or solvate of either entity.