US 6,673,780 B2 · Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses

Abstract

The present invention relates to novel sulfoxide and bis-sulfoxide compounds, compositions comprising sulfoxide and bis-sulfoxide compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.

Claims9

Dependent claims

A compound of formula II:

or pharmaceutically acceptable salt, hydrate, solvate, clathrate, stereoisomer, diastereomer, geometric isomer, or mixtures thereof, wherein
(a) R1 and R2 are independently (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, phenyl, or benzyl or R1, R2, and the carbon to which they are both attached are taken together to form a (C3-C7)cycloalkyl group;
(b) each occurrence of n is independently an integer ranging from 1 to 5;
(c) each occurrence of m is independently an integer ranging from 0 to 4;
(d) W1 and W2 are independently CH2OH, COOH, CHO, OCOR3, COOR3, SO3H,
wherein:
(i) R3 is (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, phenyl, or benzyl and is unsubstituted or substituted with one or more halo, OH, (C1-C6)alkoxy, or phenyl groups,
(ii) each occurrence of R4 is independently H, (C1-C6)alkyl, (C2-C6)alkenyl, or (C2-C6)alkynyl and is unsubstituted or substituted with one or two halo, OH, (C1-C6) alkoxy, or phenyl groups;
and
(iii) each occurrence of R7 is independently H, (C1-C6)alkyl, (C2-C6)alkenyl, or (C2-C6)alkynyl.

7 more elements

A compound of the formula:

I-1 4-[4-(3-Hydroxy-3-methyl-butane-1-sulfinylmethyl)-phenylmethanesulfinyl]-2-methyl-butan-2-ol;
I-2 4-[4-(4-Hydroxy-3,3-dimethyl-butane-1-sulfinylmethyl)-phenylmethanesulfinyl]-2,2-dimethyl-butan-1-ol;
I-3 4-[4-(3-Carboxy-3-methyl-butane-1-sulfinylmethyl)-phenylmethanesulfinyl]-2,2-dimethyl-butyric acid;
I-4 4-[4-(3,3-Dimethyl-4-oxo-butane-1-sulfinylmethyl)-phenylmethanesulfinyl]-2,2-dimethyl-butyraldehyde;
I-5 4-[4-(3-Methoxycarbonyl-3-methyl-butane-1-sulfinylmethyl)-phenylmethanesulfinyl]-2,2-dimethyl-butyric acid methyl ester;
I-6 2,2-Dimethyl-4-[4-(3-methyl-3-phenoxycarbonyl-butane-1-sulfinylmethyl)-phenylmethanesulfinyl]-butyric acid phenyl ester;
I-7 4-[4-(3-Benzyloxycarbonyl-3-methyl-butylsulfanylmethyl)-benzylsulfanyl]-2,2-dimethyl-butyric acid benzyl ester;
I-8 2-Methyl-4-[4-(3-methyl-3-sulfo-butylsulfanylmethyl)-benzylsulfanyl]-butane-2-sulfonic acid;
I-9 Phosphoric acid mono-{1,1-dimethyl-3-[4-(3-methyl-3-phosphonooxy-butylsulfanylmethyl)-benzylsulfanyl]-propyl}ester;
I-10 4-[4-(3-Hydroxy-3-methyl-butylsulfanyl)-phenylsulfanyl]-2-methyl-butan-2-ol;
I-11 4-[4-(4-Hydroxy-3,3-dimethyl-butylsulfanyl)-phenylsulfanyl]-2,2-dimethyl-butan-1-ol;
I-12 4-[4-(3-Carboxy-3-methyl-butylsulfanyl)-phenylsulfanyl]-2,2-dimethyl-butyric acid;
I-13 4-[4-(3,3-Dimethyl-4-oxo-butylsulfanyl)-phenylsulfanyl]-2,2-dimethyl-butyraldehyde;
I-14 4-[4-(3-Methoxycarbonyl-3-methyl-butylsulfanyl)-phenylsulfanyl]-2,2-dimethyl-butyric acid methyl ester;
I-15 2,2-Dimethyl-4-[4-(3-methyl-3-phenoxycarbonyl-butylsulfanyl)-phenylsulfanyl]-butyric acid phenyl ester;
I-16 4-[4-(3-Benzyloxycarbonyl-3-methyl-butylsulfanyl)-phenylsulfanyl]-2,2-dimethyl-butyric acid benzyl ester;
I-17 2-Methyl-4-[4-(3-methyl-3-sulfo-butylsulfanyl)-phenylsulfanyl]-butane-2-sulfonic acid;
I-18 Phosphoric acid mono-{1,1-dimethyl-3-[4-(3-methyl-3-phosphonooxy-butylsulfanyl)-phenylsulfanyl]-propyl}ester;
Ib-1 4-[3-(3-Hydroxy-3-methyl-butane-1-sulfinyl)-propane-1-sulfinyl]-2-methyl-butan-2-ol;
Ib-2 4-[3-(4-Hydroxy-3,3-dimethyl-butane-1-sulfinyl)-propane-1-sulfinyl]-2,2-dimethyl-butan-1-ol;
Ib-3 4-[3-(3-Carboxy-3-methyl-butane-1-sulfinyl)-propane-1-sulfinyl]-2,2-dimethyl-butyric acid;
Ib-4 4-[3-(3,3-Dimethyl-4-oxo-butane-1-sulfinyl)-propane-1-sulfinyl]-2,2-dimethyl-butyraldehyde;
Ib-5 4-[3-(3-Methoxycarbonyl-3-methyl-butane-1-sulfinyl)-propane-1-sulfinyl]-2,2-dimethyl-butyric acid methyl ester;
Ib-6 2,2-Dimethyl-4-[3-(3-methyl-3-phenoxycarbonyl-butane-1-sulfinyl)-propane-1-sulfinyl]-butyric acid phenyl ester;
Ib-7 4-[3-(3-Benzyloxycarbonyl-3-methyl-butylsulfanyl)-propylsulfanyl]-2,2-dimethyl-butyric acid benzyl ester;
Ib-8 2-Methyl-4-[3-(3-methyl-3-sulfo-butane-1-sulfinyl)-propane-1-sulfinyl]-butane-2-sulfonic acid;
Ib-9 Phosphoric acid mono-{(1,1-dimethyl-3-[3-(3-methyl-3-phosphonooxy-butane-1-sulfinyl)-propane-1-sulfinyl]-propyl}ester;
Ib-10 5-{1,1-Dimethyl-3-[3-(3-methyl-3-{3,3a-Dihydro-2H-thieno[3,2-c]pyridine-4,6-dione}-butane-1-sulfinyl)-propane-1-sulfinyl]-propyl}-3,3a-dihydro-2H-thieno[3,2-c]pyridine-4,6-dione;
Ib-11 5-{1,1-Dimethyl-3-[3-(3-methyl-3-{3,3a-Dihydro-2H-thieno[3,2-c]pyridine-4,6-dithione}-butane-1-sulfinyl)-propane-1-sulfinyl]-propyl}-3,3a-dihydro-2H-thieno[3,2-c]pyridine-4,6-dithione;
Ib-12 4-[3-(3-Cyanocarbamoyl-3-methyl-butane-1-sulfinyl)-propane-1-sulfinyl]-2,2-dimethyl-butyrcyanimide;
Ib-13 Phosphoramidic acid mono-(3-(3-[3-(amino-hydroxy-phosphoryloxy)-3-methyl-butane-1-sulfinyl]-propane-1-sulfinyl}-1,1-dimethyl-propyl)ester
Ib-14 3-(Amino-hydroxy-phosphoryloxy)-3-methyl-1-[3-(3-{amino-hydroxy-phosphoryloxy}-3-methyl-butane-1-sulfinyl)-propane-1-sulfinyl]-butane;
Ib-15 1-{1,1-Dimethyl-3-[3-(3-methyl-3-{1H-tetrazol-1-yl}-butane-1-sulfinyl)-propane-1-sulfinyl]-propyl}-1H-tetrazole;
Ib-16 1-{1,1-Dimethyl-3-[3-(3-methyl-3-{1H-tetrazol-5-yl}-butane-1-sulfinyl)-propane-1-sulfinyl]-propyl}-1H-tetrazole;
Ib-17 5-{1,1-Dimethyl-3-[3-(3-{Isoxazol-3-ol-5-yl}-3-methyl-butane-1-sulfinyl)-propane-1-sulfinyl]-propyl}-isoxazol-3-ol;
Ib-18 4-{1,1-Dimethyl-3-[3-(3-{Isoxazol-3-ol-4-yl}-3-methyl-butane-1-sulfinyl)-propane-1-sulfinyl]-propyl}-isoxazol-3-ol;
Ib-19 3-{1,1-Dimethyl-3-[3-(3-{5-hydroxy-pyran-4-one-3-yl}-3-methyl-butane-1-sulfinyl)-propane-1-sulfinyl]-propyl}-5-hydroxy-pyran-4-one;
Ib-20 2-{1,1-Dimethyl-3-[3-(3-{5-hydroxy-pyran-4-one-2-yl}-3-methyl-butane-1-sulfinyl)-propane-1-sulfinyl]-propyl}-5-hydroxy-pyran-4-one;
Ib-21 1-Ethyl-3-(3-{3-[3-(3-ethyl-2,5-dithioxo-imidazolidin-1-yl)-3-methyl-butane-1-sulfinyl]-propane-1-sulfinyl}-1,1-dimethyl-propyl)-imidazolidine-2,4-dione;
Ib-22 3-{1,1-Dimethyl-3-[3-(3-{1-ethyl-imidazolidine-2,4-dione-3-yl}-3-methyl-butane-1-sulfinyl)-propane-1-sulfinyl]-propyl}-1-ethyl-imidazolidine-2,4-dione;
Ib-23 3-{1,1-Dimethyl-3-[3-(3-{1-ethyl-imidazolidine-2-one-4-thione-3-yl}-3-methyl-butane-1-sulfinyl)-propane-1-sulfinyl]-propyl)}-1-ethyl-imidazolidine-2-one-4-thione;
Ib-24 3-{1,1-Dimethyl-3-[3-(3-{1-ethyl-imidazolidine-4-one-2-thione-3-yl}-3-methyl-butane-1-sulfinyl)-propane-1-sulfinyl]-propyl}-1-ethyl-imidazolidine-4-one-2-thione;
Ib-25 5-[3-(5-Hydroxy-3,3-dimethyl-pentylsulfanyl)-propylsulfanyl]-3,3-dimethyl-pentan-1-ol;
Ib-26 5-[3-(4-Carboxy-3,3-dimethyl-butane-1-sulfinyl)-propane-1-sulfinyl]-3,3-dimethyl-pentanoic acid;
Ib-27 5-[3-(3,3-Dimethyl-5-oxo-pentane-1-sulfinyl)-propane-1-sulfinyl]-3,3-dimethyl-pentanal;
Ib-28 5-[3-(4-Methoxycarbonyl-3,3-dimethyl-butane-1-sulfinyl)-propane-1-sulfinyl]-3,3-dimethyl-pentanoic acid methyl ester;
Ib-29 3,3-Dimethyl-5-[3-(3-methyl-3-phenoxycarbonyl-butane-1-sulfinyl)-propane-1-sulfinyl]-pentanoic acid phenyl ester;
Ib-30 5-[3-(3-Benzyloxycarbonyl-3-methyl-butane-1-sulfinyl)-propane-1-sulfinyl]-3,3-dimethyl-pentanoic acid benzyl ester;
Ib-31 4-[3-(3,3-Dimethyl-4-sulfo-butane-1-sulfinyl)-propane-1-sulfinyl]-2,2-dimethyl-butane-1-sulfonic acid;
Ib-32 Phosphoric acid mono-{4-[3-(3,3-dimethyl-4-phosphonooxy-butane-1-sulfinyl)-propane-1-sulfinyl]-2,2-dimethyl-butyl}ester;
Ib-33 5-{4-[3-(3,3-Dimethyl-4-{3,3a-dihydro-2H-thieno [3,2-c]pyridine-4,6-dione}-butane-1-sulfinyl)-propane-1-sulfinyl]-2,2-dimethyl-butyl}-3,3a-dihydro-2H-thieno[3,2-c]pyridine-4,6-dione;
Ib-34 5-{4-[3-(3,3-Dimethyl-4-{3,3a-dihydro-2H-thieno[3,2-c]pyridine-4,6-dithione}-butane-1-sulfinyl)-propane-1-sulfinyl]-2,2-dimethyl-butyl}-3,3a-dihydro-2H-thieno[3,2-c]pyridine-4,6-dithione;
Ib-35 5-[3-(4-Cyanocarbamoyl-3,3-dimethyl-butane-1-sulfinyl)-propane-1-sulfinyl]-3,3-dimethyl-pentanoic acid cyanamide;
Ib-36 Phosphoramidic acid mono-(4-{3-[4-(amino-hydroxy-phosphoryloxy)-3,3-dimethyl-butane-1-sulfinyl]-propane-1-sulfinyl}-2,2-dimethyl-butyl)ester;
Ib-37 1-{4-[3-(3,3-Dimethyl-4-{tetrazol-1-yl}-butane-1-sulfinyl)-propane-1-sulfinyl]-2,2-dimethyl-butyl}-1H-tetrazole;
Ib-38 1-{4-[3-(3,3-Dimethyl-4-{tetrazol-5-yl}-butane-1-sulfinyl)-propane-1-sulfinyl]-2,2-dimethyl-butyl}-1H-tetrazole;
Ib-39 5-{4-[3-(3,3-Dimethyl-4-{isoxazol-3-ol-5-yl}-butane-1-sulfinyl)-propane-1-sulfinyl]-2,2-dimethyl-butyl}-isoxazol-3-ol;
Ib-40 4-{4-[3-(3,3-Dimethyl-4-{isoxazol-3-ol-4-yl}-butane-1-sulfinyl)-propane-1-sulfinyl]-2,2-dimethyl-butyl}-isoxazol-3-ol;
Ib-41 3-{4-[3-(3,3-Dimethyl-4-{5-hydroxy-pyran-4-one-3-yl}-butane-1-sulfinyl)-propane-1-sulfinyl]-2,2-dimethyl-butyl}-5-hydroxy-pyran-4-one;
Ib-42 2-{4-[3-(3,3-Dimethyl-4-{5-hydroxy-pyran-4-one-2-yl}-butane-1-sulfinyl)-propane-1-sulfinyl]-2,2-dimethyl-butyl}-5-hydroxy-pyran-4-one;
Ib-43 3-{4-[3-(3,3-Dimethyl-4-{5-Hydroxy-pyran-4-one-2-yl}-butane-1-sulfinyl)-propane-1-sulfinyl]-2,2-dimethyl-butyl}-5-hydroxy-pyran-4-one;
Ib-44 1-Ethyl-3-(4-{3-[4-(3-ethyl-2,5-dithioxo-imidazolidin-1-yl)-3,3-dimethyl-butane-1-sulfinyl]-propane-1-sulfinyl}-2,2-dimethyl-butyl)-imidazolidine-2,4-dione;
Ib-45 1-Ethyl-3-(4-{3-[4-(3-ethyl-2,5-dioxo-imidazolidin-1-yl)-3,3-dimethyl-butane-1-sulfinyl]-propane-1-sulfinyl}-2,2-dimethyl-butyl)-imidazolidine-2,4-dione;
Ib-46 1-Ethyl-3-(4-{3-[4-(3-ethyl-2,5-dithioxo-imidazolidin-1-yl)-3,3-dimethyl-butane-1-sulfinyl]-propane-1-sulfinyl}-2,2-dimethyl-butyl)-imidazolidine-2,4-dithione;
Ib-47 1-Ethyl-3-(4-{3-[4-(3-ethyl-2-oxo-5-thio-imidazolidin-1-yl)-3,3-dimethyl-butane-1-sulfinyl]-propane-1-sulfinyl}-2,2-dimethyl-butyl)-imidazolidine-2-one-4-thione;
Ib-48 1-Ethyl-3-(4-{3-[4-(3-ethyl-2-thioxo-5-oxo-imidazolidin-1-yl)-3,3-dimethyl-butane-1-sulfinyl]-propane-1-sulfinyl}-2,2-dimethyl-butyl)-imidazolidine-2-thione-4-one;
Ib-49 4-[2-(3-Hydroxy-3-methyl-butane-1-sulfinyl)-ethanesulfinyl]-2-methyl-butan-2-ol;
Ib-50 4-[2-(4-Hydroxy-3,3-dimethyl-butane-1-sulfinyl)-ethanesulfinyl]-2,2-dimethyl-butan-1-ol;
Ib-51 4-[2-(3-Carboxy-3-methyl-butane-1-sulfinyl)-ethanesulfinyl]-2,2-dimethyl-butyric acid;
Ib-52 2-Methyl-4-[2-(3-methyl-3-sulfo-butane-1-sulfinyl)-ethanesulfinyl]-butane-2-sulfonic acid;
Ib-53 4-[2-(3,3-Dimethyl-4-oxo-butane-1-sulfinyl)-ethanesulfinyl]-2,2-dimethyl-butyraldehyde;
Ib-54 4-[2-(3-Methoxycarbonyl-3-methyl-butane-1-sulfinyl)-ethanesulfinyl]-2,2-dimethyl-butyric acid methyl ester;
Ib-55 2,2-Dimethyl-4-[2-(3-methyl-3-phenoxycarbonyl-butane-1-sulfinyl)-ethanesulfinyl]-butyric acid phenyl ester;
Ib-56 4-[2-(3-Benzyloxycarbonyl-3-methyl-butane-1-sulfinyl)-ethanesulfinyl]-2,2-dimethyl-butyric acid benzyl ester;
Ib-57 Phosphoric acid mono-{1,1-dimethyl-3-[2-(3-methyl-3-phosphonooxy-butane-1-sulfinyl)-ethanesulfinyl]-propyl}ester;
Ib-58 5-[3-(4-Hydroxy-4-methyl-pentane-1-sulfinyl)-propane-1-sulfinyl]-2-methyl-pentan-2-ol;
Ib-59 5-[3-(5-Hydroxy-4,4-dimethyl-pentane-1-sulfinyl)-propane-1-sulfinyl]-2,2-dimethyl-pentan-1-ol;
Ib-60 5-[3-(4-Carboxy-4-methyl-pentane-1-sulfinyl)-propane-1-sulfinyl]-2,2-dimethyl-pentanoic acid;
Ib-61 5-[3-(4,4-Dimethyl-5-oxo-pentane-1-sulfinyl)-propane-1-sulfinyl]-2,2-dimethyl-pentanal;
Ib-62 5-[3-(4-Methoxycarbonyl-4-methyl-pentane-1-sulfinyl)-propane-1-sulfinyl]-2,2-dimethyl-pentanoic acid methyl ester;
Ib-63 3,3-Dimethyl-6-[3-(4-methyl-4-phenoxycarbonyl-pentane-1-sulfinyl)-propane-1-sulfinyl]-hexanoic acid phenyl ester;
Ib-64 6-[3-(4-Benzyloxycarbonyl-4-methyl-pentane-1-sulfinyl)-propane-1-sulfinyl]-3,3-dimethyl-hexanoic acid benzyl ester;
Ib-65 2-Methyl-5-[3-(4-methyl-4-sulfo-pentane-1-sulfinyl)-propane-1-sulfinyl]-pentane-2-sulfonic acid;
Ib-66 Phosphoric acid mono-{1,1-dimethyl-4-[3-(4-methyl-4-phosphonooxy-pentane-1-sulfinyl)-propane-1-sulfinyl]-butyl}ester;
Ib-67 5-{1,1-Dimethyl-4-[3-(4-methyl-4-{3,3a-dihydro-2H-thieno[3,2-c]-4,6-dioxo-pyridine-5-yl}-pentane-1-sulfinyl)-propane-1-sulfinyl]-butyl}-3,3a-dihydro-2H-thieno[3,2-c]pyridine-4,6-dione;
Ib-68 5-{1,1-Dimethyl-4-[3-(4-methyl-4-{3,3a-dihydro-2H-thieno[3,2-c]-4,6-dithioxo-pyridine-5-yl}-pentane-1-sulfinyl)-propane-1-sulfinyl]-butyl}-3,3a-dihydro-2H-thieno[3,2-c]pyridine-4,6-dithione;
Ib-69 5-[3-(4-Cyanocarbamoyl-4-methyl-pentane-1-sulfinyl)-propane-1-sulfinyl]-2,2-dimethyl-pentanoic acid cyanamide;
Ib-70 Phosphoramidic acid mono-(4-{3-[4-(amino-hydroxy-phosphoryloxy)-4-methyl-pentane-1-sulfinyl]-propane-1-sulfinyl}-1,1-dimethyl-butyl)ester;
Ib-71 4-(Amino-hydroxy-phosphoryloxy)-4-methyl-1-[3-(4-{amino-hydroxy-phosphoryloxy}-4-methyl-pentane-1-sulfinyl)-propane-1-sulfinyl]-pentane;
Ib-72 5-(1,1-Dimethyl-4-{3-[4-methyl-4-(3H-[1,2,3]triazol-1-yl)-pentane-1-sulfinyl]-propane-1-sulfinyl}-butyl)-1H-tetrazole;
Ib-73 5-(1,1-Dimethyl-4-{3-[4-methyl-4-(3H-[1,2,3]triazol-4-yl)-pentane-1-sulfinyl]-propane-1-sulfinyl}-butyl)-1H-tetrazole;
Ib-74 5-{1,1-Dimethyl-4-[3-(4-{isoxazol-3-ol-5-yl}-4-methyl-pentane-1-sulfinyl)-propane-1-sulfinyl]-butyl}-isoxazol-3-ol;
Ib-75 4-{1,1-Dimethyl-4-[3-(4-{isoxazol-3-ol-4-yl}-4-methyl-pentane-1-sulfinyl)-propane-1-sulfinyl]-butyl}-isoxazol-3-ol;
Ib-76 3-{1,1-Dimethyl-4-[3-(4-{5-hydroxy-4-oxo-pyran-3-yl}-4-methyl-pentane-1-sulfinyl)-propane-1-sulfinyl]-butyl}-5-hydroxy-pyran-4-one;
Ib-77 2-{1,1-Dimethyl-4-[3-(4-{5-hydroxy-4-oxo-pyran-2-yl}-4-methyl-pentane-1-sulfinyl)-propane-1-sulfinyl]-butyl}-5-hydroxy-pyran-4-one;
Ib-78 3-{1,1-Dimethyl-4-[3-(4-{1-ethyl-2,4-dioxo-imidazolidine-3-yl}-4-methyl-pentane-1-sulfinyl)-propane-1-sulfinyl]-butyl}-1-ethyl-imidazolidine-2,4-dione;
Ib-79 3-{1,1-Dimethyl-4-[3-(4-{1-ethyl-2,4-dithioxo-imidazolidine-3-yl}-4-methyl-pentane-1-sulfinyl)-propane-1-sulfinyl]-butyl}-1-ethyl-imidazolidine-2,4-dithione;
Ib-80 3-{1,1-Dimethyl-4-[3-(4-{1-ethyl-2-thixoxo-4-oxo-imidazolidine-3-yl}-4-methyl-pentane-1-sulfinyl)-propane-1-sulfinyl]-butyl}-1-ethyl-imidazolidine-2-thione-4-one;
Ib-81 3-{1,1-Dimethyl-4-[3-(4-{1-ethyl-2-one-4-thioxo-imidazolidine-3-yl}-4-methyl-pentane-1-sulfinyl)-propane-1-sulfinyl]-butyl}-1-ethyl-imidazolidine-2-one-4-thione;
Ib-81 5-[2-(5-Hydroxy-3,3-dimethyl-pentane-1-sulfinyl)-ethanesulfinyl]-3,3-dimethyl-pentan-1-ol;
Ib-82 5-[2-(4-Carboxy-3,3-dimethyl-butane-1-sulfinyl)-ethanesulfinyl]-3,3-dimethyl-pentanoic acid;
Ib-83 5-[2-(3,3-Dimethyl-5-oxo-pentane-1-sulfinyl)-ethanesulfinyl]-3,3-dimethyl-pentanal;
Ib-84 5-[2-(4-Methoxycarbonyl-3,3-dimethyl-butane-1-sulfinyl)-ethanesulfinyl]-3,3-dimethyl-pentanoic acid methyl ester;
Ib-85 5-[2-(3,3-Dimethyl-4-phenoxycarbonyl-butane-1-sulfinyl)-ethanesulfinyl]-3,3-dimethyl-pentanoic acid phenyl ester;
Ib-86 5-[2-(4-Benzyloxycarbonyl-3,3-dimethyl-butane-1-sulfinyl)-ethanesulfinyl]-3,3-dimethyl-pentanoic acid benzyl ester;
Ib-87 4-[2-(3,3-Dimethyl-4-sulfo-butane-1-sulfinyl)-ethanesulfinyl]-2,2-dimethyl-butane-1-sulfonic acid;
Ib-88 Phosphoric acid mono-{4-[2-(3,3-dimethyl-4-phosphonooxy-butane-1-sulfinyl)-ethanesulfinyl]-2,2-dimethyl-butyl}ester;
Ib-89 5-{4-[2-(3,3-Dimethyl-4-{3,3a-dihydro-4,6-dioxo-2H-thieno[3,2-c]pyridine-5-yl}-butane-1-sulfinyl)-ethanesulfinyl]-2,2-dimethyl-butyl}-3,3a-dihydro-2H-thieno[3,2-c]pyridine-4,6-dione;
Ib-90 5-{4-[2-(3,3-Dimethyl-4-{3,3a-dihydro-4,6-dithioxo-2H-thieno[3,2-c]pyridine-5-yl}-butane-1-sulfinyl)-ethanesulfinyl]-2,2-dimethyl-butyl}-3,3a-dihydro-2H-thieno[3,2-c]pyridine-4,6-dithione;
Ib-91 5-[2-(4-Cyanocarbamoyl-3,3-dimethyl-butane-1-sulfinyl)-ethanesulfinyl]-3,3-dimethyl-pentanoic acid cyanamide;
Ib-92 Phosphoramidic acid mono-(4-{2-[4-(amino-hydroxy-phosphoryloxy)-3,3-dimethyl-butane-1-sulfinyl]-ethanesulfinyl}-2,2-dimethyl-butyl)ester;
Ib-93 1-[2-(3,3-Dimethyl-4{amino-hydroxy-phosphoryloxy}-butane-1-sulfinyl)-ethanesulfinyl]-3,3-dimethyl-4{amino-hydroxy-phosphoryloxy}-butane;
Ib-94 5-{4-[2-(3,3-Dimethyl-4-tetrazol-5-yl-butane-1-sulfinyl)-ethanesulfinyl]-2,2-dimethyl-butyl}-1H-tetrazole;
Ib-95 5-{4-[2-(3,3-Dimethyl-4-tetrazol-1-yl-butane-1-sulfinyl)-ethanesulfinyl]-2,2-dimethyl-butyl}-1H-tetrazole;
Ib-96 5-{4-[2-(3,3-Dimethyl-4-isoxazol-3-ol-5-yl-butane-1-sulfinyl)-ethanesulfinyl]-2,2-dimethyl-butyl}-isoxazol-3-ol;
Ib-97 4-{4-[2-(3,3-Dimethyl-4-isoxazol-3-ol-4-yl-butane-1-sulfinyl)-ethanesulfinyl]-2,2-dimethyl-butyl}-isoxazol-3-ol;
Ib-98 3-{4-[2-(3,3-Dimethyl-4-{5-hydroxy-4-oxy-pyran-3-yl}-butane-1-sulfinyl)-ethanesulfinyl]-2,2-dimethyl-butyl}-5-hydroxy-pyran-4-one;
Ib-99 2-{4-[2-(3,3-Dimethyl-4-{5-hydroxy-4-oxy-pyran-3-yl}-butane-1-sulfinyl)-ethanesulfinyl]-2,2-dimethyl-butyl}-5-hydroxy-pyran-4-one;
Ib-100 2-{4-[2-(3,3-Dimethyl-4-{5-hydroxy-4-oxy-pyran-2-yl}-butane-1-sulfinyl)-ethanesulfinyl]-2,2-dimethyl-butyl}-5-hydroxy-pyran-4-one;
Ib-101 3-{4-[2-(3,3-Dimethyl-4-{1-Ethyl-2,4-dithioxo-imidazolidine-3-yl}-butane-1-sulfinyl)-ethanesulfinyl]-2,2-dimethyl-butyl}-1-ethyl-imidazolidine-2,4-dithione;
Ib-102 1-Ethyl-3-(4-{2-[4-(3-ethyl-2,5-dithioxo-imidazolidin-1-yl)-3,3-dimethyl-butane-1-sulfinyl]-ethanesulfinyl}-2,2-dimethyl-butyl)-imidazolidine-2,4-dione;
Ib-103 1-Ethyl-3-(4-{2-[4-(3-ethyl-2,5-dioxo-imidazolidin-1-yl)-3,3-dimethyl-butane-1-sulfinyl]-ethanesulfinyl}-2,2-dimethyl-butyl)-imidazolidine-2,4-dione;
Ib-104 1-Ethyl-3-(4-{2-[4-(3-ethyl-2-thioxo-5-oxo-imidazolidin-1-yl)-3,3-dimethyl-butane-1-sulfinyl]-ethanesulfinyl}-2,2-dimethyl-butyl)-imidazolidine-2-thione-4-one;
Ib-105 1-Ethyl-3-(4-{2-[4-(3-ethyl-2-oxo-5-thioxo-imidazolidin-1-yl)-3,3-dimethyl-butane-1-sulfinyl]-ethanesulfinyl}-2,2-dimethyl-butyl)-imidazolidine-2-one-4-thione;
Ib-106 6-[2-(6-Hydroxy-3,3-dimethyl-hexane-1-sulfinyl)-ethanesulfinyl]-4,4-dimethyl-hexan-1-ol;
Ib-107 6-[2-(5-Carboxy-3,3-dimethyl-pentane-1-sulfinyl)-ethanesulfinyl]-4,4-dimethyl-hexanoic acid;
Ib-108 6-[2-(3,3-Dimethyl-6-oxo-hexane-1-sulfinyl)-ethanesulfinyl]-4,4-dimethyl-hexanal;
Ib-109 6-[2-(5-Methoxycarbonyl-3,3-dimethyl-pentane-1-sulfinyl)-ethanesulfinyl]-4,4-dimethyl-hexanoic acid methyl ester;
Ib-110 6-[2-(3,3-Dimethyl-5-phenoxycarbonyl-pentane-1-sulfinyl)-ethanesulfinyl]-4,4-dimethyl-hexanoic acid phenyl ester;
Ib-111 6-[2-(5-Benzyloxycarbonyl-3,3-dimethyl-pentane-1-sulfinyl)-ethanesulfinyl]-4,4-dimethyl-hexanoic acid benzyl ester;
Ib-112 5-[2-(3,3-Dimethyl-5-sulfo-pentane-1-sulfinyl)-ethanesulfinyl]-3,3-dimethyl-pentane-1-sulfonic acid;
Ib-113 Phosphoric acid mono-{5-[2-(3,3-dimethyl-5-phosphonooxy-pentane-1-sulfinyl)-ethanesulfinyl]-3,3-dimethyl-pentyl}ester;
Ib-114 5-{5-[2-(3,3-Dimethyl-4-{3,3a-dihydro-4,6-dioxo-2H-thieno[3,2-c]pyridin-5yl}-pentane-1-sulfinyl)-ethanesulfinyl]-3,3-dimethyl-pentyl}-3,3a-dihydro-2H-thieno[3,2-c]pyridine-4,6-dione;
Ib-115 5-{5-[2-(3,3-Dimethyl-4-{3,3a-dihydro-4,6-dithioxo-2H-thieno[3,2-c]pyridin-5-yl}-pentane-1-sulfinyl)-ethanesulfinyl]-3,3-dimethyl-pentyl}-3,3a-dihydro-2H-thieno[3,2-c]pyridine-4,6-dithione;
Ib-116 6-[2-(5-Cyanocarbamoyl-3,3-dimethyl-pentane-1-sulfinyl)-ethanesulfinyl]-4,4-dimethyl-hexanoic acid cyanimide;
Ib-117 Phosphoramidic acid mono-(5-{2-[5-(amino-hydroxy-phosphoryloxy)-3,3-dimethyl-pentane-1-sulfinyl]-ethanesulfinyl}-3,3-dimethyl-pentyl)ester;
Ib-118 1-[2-(3,3-Dimethyl-5-{amino-hydroxy-phosphoryloxy}-pentane-1-sulfinyl)-ethanesulfinyl]-3,3-dimethyl-5-{amino-hydroxy-phosphoryloxy}-pentane;
Ib-119 4-[2-(4-Hydroxy-3,3-dimethyl-butane-1-sulfinyl)-ethanesulfinyl]-2,2-dimethyl-butan-1-ol;
Ib-120 4-[2-(3-Carboxy-3-methyl-butane-1-sulfinyl)-ethanesulfinyl]-2,2-dimethyl-butyric acid;
Ib-121 4-[2-(3,3-Dimethyl-4-oxo-butane-1-sulfinyl)-ethanesulfinyl]-2,2-dimethyl-butyraldehyde;
Ib-122 4-[2-(3-Methoxycarbonyl-3-methyl-butane-1-sulfinyl)-ethanesulfinyl]-2,2-imethyl-butyric acid methyl ester;
Ib-123 2,2-Dimethyl-4-[2-(3-methyl-3-phenoxycarbonyl-butane-1-sulfinyl)-thanesulfinyl]-butyric acid phenyl ester;
Ib-124 4-[2-(3-Benzyloxycarbonyl-3-methyl-butane-1-sulfinyl)-ethanesulfinyl]-2,2-dimethyl-butyric acid benzyl ester;
Ib-125 2-Methyl-4-[2-(3-methyl-3-sulfo-butane-1-sulfinyl)-ethanesulfinyl]-butane-2-sulfonic acid;
Ib-126 Phosphoric acid mono-{1,1-dimethyl-3-[2-(3-methyl-3-phosphonooxy-utane-1-sulfinyl)-ethanesulfinyl]-propyl}ester;
Ib-127 5-{1,1-Dimethyl-3-[2-(3-methyl-3-{3,3a-dihydro-4,6-dioxo-2H-thieno[3,2-c]yridine-5-yl}-butane-1-sulfinyl)-ethanesulfinyl]-propyl}-3,3a-dihydro-2H-thieno[3,2-c]pyridine-4,6-dione;
Ib-128 5-{1,1-Dimethyl-3-[2-(3-methyl-3-{3,3a-dihydro-4,6-dithioxo-2H-thieno[3,2-c]yridine-5-yl}-butane-1-sulfinyl)-ethanesulfinyl]-propyl}-3,3a-dihydro-2H-thieno3,2-c]pyridine-4,6-ithione;
Ib-129 4-[2-(3-Cyanocarbamoyl-3-methyl-butane-1-sulfinyl)-ethanesulfinyl]-2,2-dimethyl-butyrcyanimide;
Ib-130 Phosphoramidic acid mono-(3-{2-[3-(amino-hydroxy-phosphoryloxy)-3-ethyl-butane-1-sulfinyl]-ethanesulfinyl}-1,1-dimethyl-propyl)ester;
Ib-131 1-[2-(3,3-Dimethyl-4-{amino-hydroxy-phosphoryloxy}-butane-1-sulfinyl)-ethanesulfinyl]-3,3-dimethyl-4-{amino-hydroxy-phosphoryloxy}-butane;
Ib-132 1-{5-[2-(3,3-Dimethyl-5-{tetrazol-1-yl}-pentane-1-sulfinyl)-ethylsulfanyl]-3,3-dimethyl-pentyl}-1H-tetrazole;
Ib-133 5-{5-[2-(3,3-Dimethyl-5-{tetrazol-5-yl}-pentane-1-sulfinyl)-ethylsulfanyl]-3,3-dimethyl-pentyl}-1H-tetrazole;
Ib-134 5-{5-[2-(3,3-Dimethyl-5-(isoxazol-3-ol-5-yl}-pentane-1-sulfinyl)-ethanesulfinyl]-,3-imethyl-pentyl}-isoxazol-3-ol;
Ib-135 4-{5-[2-(3,3-Dimethyl-5-(isoxazol-3-ol-4-yl}-pentane-1-sulfinyl)-ethanesulfinyl]-3,3-imethyl-pentyl}-isoxazol-3-ol;
Ib-136 2-{5-[2-(3,3-Dimethyl-5-{5-Hydroxy-4-oxy-pyran-3-yl}-pentane-1-sulfinyl)-ethanesulfinyl]-3,3-dimethyl-pentyl}-5-hydroxy-pyran-4-one;
Ib-137 2-{5-[2-(3,3-Dimethyl-5-{5-Hydroxy-4-oxy-pyran-2-yl}-pentane-1-sulfinyl)-thanesulfinyl]-3,3-dimethyl-pentyl}-5-hydroxy-pyran-4-one;
Ib-138 3-{5-[2-(3,3-Dimethyl-5-{5-Hydroxy-4-oxy-pyran-3-yl}-pentane-1-sulfinyl)-ethanesulfinyl]-3,3-dimethyl-pentyl}-5-hydroxy-pyran-4-one;
Ib-139 1-Ethyl-3-(5-{2-[5-(3-ethyl-2,5-dithioxo-imidazolidin-1-yl)-3,3-dimethyl-pentane-1-sulfinyl]-ethanesulfinyl}-3,3-dimethyl-pentyl)-imidazolidine-2,4-dione;
Ib-140 1-Ethyl-3-(5-{2-[5-(3-ethyl-2,5-dioxo-imidazolidin-1-yl)-3,3-dimethyl-pentane-1-sulfinyl]-ethanesulfinyl}-3,3-dimethyl-pentyl)-imidazolidine-2,4-dione;
Ib-141 1-Ethyl-3-(5-{2-[5-(3-ethyl-2,5-dithioxo-imidazolidin-1-yl)-3,3-dimethyl-pentane-1-ulfinyl]-ethanesulfinyl}-3,3-dimethyl-pentyl)-imidazolidine-2,4-dithione;
Ib-142 1-Ethyl-3-(5-{2-[5-(3-ethyl-2-thioxo-5-oxo-imidazolidin-1-yl)-3,3-dimethyl-pentane-1-ulfinyl]-ethanesulfinyl}-3,3-dimethyl-pentyl)-imidazolidine-2-thione-4-one;
Ib-143 1-Ethyl-3-(5-{2-[5-(3-ethyl-2-oxo-5-thioxo-imidazolidin-1-yl)-3,3-dimethyl-pentane-1-sulfinyl]-ethanesulfinyl}-3,3-dimethyl-pentyl)-imidazolidine-2-one-4-thione;
Ib-144 6-[3-(5-Carboxy-4,4-dimethyl-pentane-1-sulfinyl)-propane-1-sulfinyl]-3,3-dimethyl-hexanoic acid;
Ib-145 6-[3-(4,4-Dimethyl-6-oxo-hexane-1-sulfinyl)-propane-1-sulfinyl]-3,3-dimethyl-hexanal;
Ib-146 6-[3-(5-Methoxycarbonyl-4,4-dimethyl-pentane-1-sulfinyl)-propane-1-sulfinyl]-3,3-dimethyl-hexanoic acid methyl ester;
Ib-147 6-[3-(6-Hydroxy-4,4-dimethyl-hexane-1-sulfinyl)-propane-1-sulfinyl]-3,3-dimethyl-hexan-1-ol;
Ib-148 6-[3-(4,4-Dimethyl-5-phenoxycarbonyl-pentane-1-sulfinyl)-propane-1-sulfinyl]-3,3-dimethyl-hexanoic acid phenyl ester;
Ib-149 6-[3-(5-Benzyloxycarbonyl-4,4-dimethyl-pentane-1-sulfinyl)-propane-1-sulfinyl]-3,3-dimethyl-hexanoic acid benzyl ester;
Ib-150 5-(3-{2-[3-(3-Ethyl-2,6-dioxo-3,6-dihydro-2H-pyridin-1-yl)-3-methyl-butane-1-sulfinyl]-ethanesulfinyl}-1,1-dimethyl-propyl)-3,3a-dihydro-2H-thieno[3,2-c]pyridine-4,6-dione;
Ib-151 3-(3,3a-Dihydro-2H-thieno[3,2-c]pyridine-4,6-dithione)-3-methyl-1-[2-(3-{3,3a-Dihydro-2H-thieno[3,2-c]pyridine-4,6-dithione}-3-methyl-butane-1-sulfinyl)-ethanesulfinyl]-butane;
Ib-152 4-[2-(3-Cyanocarbamoyl-3-methyl-butane-1-sulfinyl)-ethanesulfinyl]-2,2-dimethyl-cyanobutyramide;
Ib-153 Phosphoramidic acid mono-(3-{2-[3-(amino-hydroxy-phosphoryloxy)-3-methyl-butane-1-sulfinyl]-ethanesulfinyl}-1,1-dimethyl-propyl)ester;
Ib-154 3-(Amino-hydroxy-phosphoryloxy)-3-methyl-1-[2-(3-{amino-hyroxy-phosphoyloxy}-3-methyl-butane-1-sulfinyl)-ethanesulfinyl]-butane;
Ib-155 3-Methyl-3-tetrazol-1-yl-1-[2-(3-methyl-3-tetrazol-1-yl-butane-1-sulfinyl)-ethanesulfinyl]-butane;
Ib-156 3-Methyl-3-1H-tetrazol-5-yl-1-[2-(3-methyl-3-1H-tetrazol-5-yl-butane-1-sulfinyl)-ethanesulfinyl]-butane;
Ib-157 5-[3-(4,4-Dimethyl-5-sulfo-pentane-1-sulfinyl)-propane-1-sulfinyl]-2,2-dimethyl-pentane-1-sulfonic acid;
Ib-158 Phosphoric acid mono-{5-[3-(4,4-dimethyl-5-phosphonooxy-pentane-1-sulfinyl)-propane-1-sulfinyl]-2,2-dimethyl-pentyl}ester;
Ib-159 1-[3-(5-{3,3a-Dihydro-2H-thieno[3,2-c]pyridine-4,6-dione}-4,4-Dimethyl-pentane-1-sulfinyl)-propane-1-sulfinyl]-5-(3,3a-Dihydro-2H-thieno[3,2-c]pyridine-4,6-dione)-4,4-dimethyl-pentane;
Ib-160 1-[3-(5-{3,3a-Dihydro-2H-thieno[3,2-c]pyridine-4,6-dithione}-4,4-Dimethyl-pentane-1-sulfinyl)-propane-1-sulfinyl]-5-(3,3a-Dihydro-2H-thieno[3,2-c]pyridine-4,6-dithione)-4,4-dimethyl-pentane;
Ib-161 6-[3-(5-Cyanocarbamoyl-4,4-dimethyl-pentane-1-sulfinyl)-propane-1-sulfinyl]-3,3-dimethyl-hexanoic acid cyanamide;
Ib-162 Phosphoramidic acid mono-[16-(amino-hydroxy-phosphoryloxy)-4,4,15,15-tetramethyl-7,11-dioxo-hexadecyl]ester;
Ib-163 1-[3-(4,4-Dimethyl-5-{amino-hydroxy-phosphoryloxy}-pentane-1-sulfinyl)-propane-1-sulfinyl]-4,4-dimethyl-5-(amino-hydroxy-phosphoryloxy)-pentane;
Ib-164 4,4-Dimethyl-5-tetrazol-1-yl-1-[3-(4,4-dimethyl-5-tetrazol-1-yl-pentane-1-sulfinyl)-propane-1-sulfinyl]-pentane;
Ib-165 4,4-Dimethyl-5-1H-tetrazol-5-yl-1-[3-(4,4-dimethyl-5-1H-tetrazol-5-yl-pentane-1-sulfinyl)-propane-1-sulfinyl]-pentane;
Ib-166 1-[3-(5-isoxazol-5-yl-4,4-dimethyl-pentane-1-sulfinyl)-propane-1-sulfinyl]-5-isoxazol-5-yl-4,4-dimethyl-hexane;
Ib-167 1-[3-(5-isoxazol-4-yl-4,4-dimethyl-pentane-1-sulfinyl)-propane-1-sulfinyl]-5-isoxazol-4-yl-4,4-dimethyl-hexane;
Ib-168 1-[3-(5-{5-Hydroxy-4-oxo-4H-pyran-3-yl}-4,4-dimethyl-pentane-1-sulfinyl)-propane-1-sulfinyl]-5-(5-hydroxy-4-oxo-4H-pyran-2-yl)-4,4-dimethyl-pentane;
Ib-169 1-[3-(5-{5-Hydroxy-4-oxo-4H-pyran-2-yl}-4,4-dimethyl-pentane-1-sulfinyl)-propane-1-sulfinyl]-5-(5-hydroxy-4-oxo-4H-pyran-2-yl)-4,4-dimethyl-pentane;
Ib-170 1-[3-(5-{5-Hydroxy-4-oxo-4H-pyran-3-yl}-4,4-dimethyl-pentane-1-sulfinyl)-propane-1-sulfinyl]-5-(5-hydroxy-4-oxo-4H-pyran-3-yl)-4,4-dimethyl-pentane;
Ib-171 1-[3-(5-{1-ethyl-2,4-dithioxo-imidazolidinyl}-4,4-dimethyl-pentane-1-sulfinyl)-propane-1-sulfinyl]-5-(1-ethyl-2,4-dithioxo-imidazolidinyl)-4,4-dimethyl-pentane;
Ib-172 1-[3-(5-{1-ethyl-2,4-dithioxo-imidazolidinyl}-4,4-dimethyl-pentane-1-sulfinyl)-propane-1-sulfinyl]-5-(1-ethyl-2,4-dioxo-imidazolidinyl)-4,4-dimethyl-pentane;
Ib-173 1-[3-(5-{1-ethyl-2,4-dioxo-imidazolidinyl}-4,4-dimethyl-pentane-1-sulfinyl)-propane-1-sulfinyl]-5-(1-ethyl-2,4-dioxo-imidazolidinyl)-4,4-dimethyl-pentane;
Ib-174 1-[3-(5-{1-ethyl-2-thioxo-imidazolidin-4-one}-4,4-dimethyl-pentane-1-sulfinyl)-propane-1-sulfinyl]-4-(1-ethyl-2-thioxo-imidazolidin-4-one)-4,4-dimethyl-pentane;
Ib-175 1-[3-(5-{1-ethyl-4-thioxo-imidazolidin-2-one}-4,4-dimethyl-pentane-1-sulfinyl)-propane-1-sulfinyl]-5-(1-ethyl-4-thioxo-imidazolidin-2-one)-4,4-dimethyl-pentane;
Ib-176 5-[2-(5-Hydroxy-3,3-dimethyl-pentane-1-sulfinyl)-ethanesulfinyl]-3,3-dimethyl-pentan-1-ol;
1c-1 2-[2-(3-Tetrahydro-pyran-2-oxy-ethanesulfinyl-propane-1-sulfinyl)-ethoxy]-tetrahydro-pyran;
1c-2 4-[2-(3-2-{2-oxyoxetan-4-yl}-ethanesulfinyl-propane-1-sulfinyl)-ethyl]-oxetan-2-one;
1c-3 3-[2-(3-2-{2-oxyoxetan-3-yl}-ethanesulfinyl-propane-1-sulfinyl)-ethyl]-oxetan-2-one;
1c-4 5-[2-(3-2-{2-oxo-dihydro-furan-5-yl}-ethanesulfinyl-propane-1-sulfinyl)-ethyl]-dihydro-furan-2-one;
1c-5 4-[2-(3-2-{2-oxo-dihydro-furan-4-yl}-ethanesulfinyl-propane-1-sulfinyl)-ethyl]-dihydro-furan-2-one;
1c-6 3-[2-(3-2-{2-oxo-dihydro-furan-3-yl}-ethanesulfinyl-propane-1-sulfinyl)-ethyl]-dihydro-furan-2-one;
1c-7 [2-(2-{3-[2-(4-Carboxymethyl-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethanesulfinyl]-propane-1-sulfinyl}-ethyl)-4-hydroxy-6-oxo-tetrahydro-pyran-4-yl]-acetic acid;
1c-8 6-[2-(3-2-{2-oxo-tetrahydro-pyran-6-yl}-Ethanesulfinyl-propane-1-sulfinyl)-ethyl]-tetrahydro-pyran-2-one;
1c-9 5-[2-(3-2-{2-oxo-tetrahydro-pyran-5-yl}-Ethanesulfinyl-propane-1-sulfinyl)-ethyl]-tetrahydro-pyran-2-one;
1c-10 4-[2-(3-2-{2-oxo-tetrahydro-pyran-4-yl}-Ethanesulfinyl-propane-1-sulfinyl)-ethyl]-tetrahydro-pyran-2-one;
1c-11 3-[2-(3-2-{2-oxo-tetrahydro-pyran-3-yl}-Ethanesulfinyl-propane-1-sulfinyl)-ethyl]-tetrahydro-pyran-2-one;
1c-12 2-[3-(3-Tetrahydro-pyran-2-oxy-propanesulfinyl-propane-1-sulfinyl)-ethoxy]-tetrahydro-pyran;
1c-13 4-{3-[3-(3-{2-oxo-oxetan-4-yl}-propane-1-sulfinyl)-propane-1-sulfinyl]-propyl}-oxetan-2-one;
1c-14 3-{3-[3-(3-{2-oxo-oxetan-3-yl}-propane-1-sulfinyl)-propane-1-sulfinyl]-propyl}-oxetan-2-one;
1c-15 5-{3-[3-(3-{2-oxo-dihydro-furan-5-yl}-propane-1-sulfinyl)-propane-1-sulfinyl]-propyl}-dihydrofuran-2-one;
1c-16 4-{3-[3-(3-{2-oxo-dihydro-furan-4-yl}-propane-1-sulfinyl)-propane-1-sulfinyl]-propyl}-dihydrofuran-2-one;
1c-17 3-{3-[3-(3-{2-oxo-dihydro-furan-3-yl}-propane-1-sulfinyl)-propane-1-sulfinyl]-propyl}-dihydrofuran-2-one;
1c-18 [2-(3-{3-[3-(4-Carboxymethyl-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-propane-1-sulfinyl]-propane-1-sulfinyl}-propyl)-4-hydroxy-6-oxo-tetrahydro-pyran-4-yl]-acetic acid;
1c-19 6-{3-[3-(3-{2-oxo-tetrahydro-pyran-6-yl}-propane-1-sulfinyl)-propane-1-sulfinyl]-propyl}-tetrahydro-pyran-2-one;
1c-20 5-{3-[3-(3-{2-oxo-tetrahydro-pyran-5-yl}-propane-1-sulfinyl)-propane-1-sulfinyl]-propyl}-tetrahydro-pyran-2-one;
1c-21 4-{3-[3-(3-{2-oxo-tetrahydro-pyran-4-yl}-propane-1-sulfinyl)-propane-1-sulfinyl]-propyl}-tetrahydro-pyran-2-one;
1c-22 3-{3-[3-(3-{2-oxo-tetrahydro-pyran-3-yl}-propane-1-sulfinyl)-propane-1-sulfinyl]-propyl}-tetrahydro-pyran-2-one;
Ic-24 2-[2-(3-Tetrahydro-pyran-2-oxy-ethanesulfinyl-ethane-1-sulfinyl)-ethoxy]-tetrahydro-pyran;
Ic-25 4-[2-(2-{2-oxo-oxetan-4-yl}-ethanesulfinyl-ethanesulfinyl)-ethyl]-oxetan-2-one;
Ic-26 3-[2-(2-{2-oxo-oxetan-3-yl}-ethanesulfinyl-ethanesulfinyl)-ethyl]-oxetan-2-one;
Ic-27 5-[2-(2-{2-oxo-dihydro-furan-5-yl}-ethanesulfinyl-ethanesulfinyl)-ethyl]-dihydro-furan-2-one;
Ic-28 4-[2-(2-{2-oxo-dihydro-furan-4-yl}-ethanesulfinyl-ethanesulfinyl)-ethyl]-dihydro-furan-2-one;
Ic-29 3-[2-(2-{2-oxo-dihydro-furan-3-yl}-ethanesulfinyl-ethanesulfinyl)-ethyl]-dihydro-furan-2-one;
Ic-30 [2-(2-{2-[2-(4-Carboxymethyl-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethanesulfinyl]-ethanesulfinyl}-ethyl)-4-hydroxy-6-oxo-tetrahydro-pyran-4-yl]-acetic acid;
Ic-31 6-[2-(3-2-{2-oxo-tetrahydro-pyran-6-yl}-ethanesulfinyl-ethane-1-sulfinyl)-ethyl]-tetrahydro-pyran-2-one;
Ic-32 5-[2-(3-2-{2-oxo-tetrahydro-pyran-5-yl}-ethanesulfinyl-ethane-1-sulfinyl)-ethyl]-tetrahydro-pyran-2-one;
Ic-33 4-[2-(3-2-{2-oxo-tetrahydro-pyran-4-yl}-ethanesulfinyl-ethane-1-sulfinyl)-ethyl]-tetrahydro-pyran-2-one;
Ic-34 3-[2-(3-2-{2-oxo-tetrahydro-pyran-3-yl}-ethanesulfinyl-ethane-1-sulfinyl)-ethyl]-tetrahydro-pyran-2-one;
II-1 6-(6-Hydroxy-5,5-dimethyl-hexane-1-sulfinyl)-2,2-dimethyl-hexan-1-ol;
II-2 6-(5-Carboxy-5-methyl-hexane-1-sulfinyl)-2,2-dimethyl-hexanoic acid;
II-3 5-(5-Hydroperoxy-4,4-dimethyl-pentane-1-sulfinyl)-2,2-dimethyl-pentanoic acid;
II-4 5-(5-Hydroxy-4,4-dimethyl-pentane-1-sulfinyl)-2,2-dimethyl-pentan-1-ol;
II-5 5-(5-Hydroxy-4,4-dimethyl-pentane-1-sulfinyl)-2,2-dimethyl-pentanoic acid;
II-6 5-(4-Carboxy-4-methyl-pentane-1-sulfinyl)-2,2-dimethyl-pentanoic acid;
II-7 7-(7-Hydroxy-6,6-dimethyl-heptane-1-sulfinyl)-2,2-dimethyl-heptan-1-ol;
II-8 7-(7-Hydroxy-6,6-dimethyl-heptane-1-sulfinyl)-2,2-dimethyl-heptanoic acid;
II-9 7-(6-Carboxy-6-methyl-heptane-1-sulfinyl)-2,2-dimethyl-heptanoic acid;
II-10 6-(5,5-Dimethyl-6-oxo-hexane-1-sulfinyl)-2,2-dimethyl-hexanal;
II-11 6-(5-Methoxycarbonyl-5-methyl-hexane-1-sulfinyl)-2,2-dimethyl-hexanoic acid methyl ester;
II-12 6-(5,5-Dimethyl-6-oxo-6-phenyl-hexane-1-sulfinyl)-2,2-dimethyl-1-phenyl-hexan-1-one;
II-13 7-(5,5-Dimethyl-6-oxo-7-phenyl-heptane-1-sulfinyl)-3,3-dimethyl-1-phenyl-heptan-2-one;
II-14 2-Methyl-6-(5-methyl-5-sulfo-hexane-1-sulfinyl)-hexane-2-sulfonic acid;
II-15 Phosphoric acid mono-[1,1-dimethyl-5-(5-methyl-5-phosphonooxy-hexane-1-sulfinyl)-pentyl]ester;
II-16 7-(6,6-Dimethyl-7-oxo-heptane-1-sulfinyl)-2,2-dimethyl-heptanal;
II-17 7-(6-Methoxycarbonyl-6-methyl-heptane-1-sulfinyl)-2,2-dimethyl-heptanoic acid methyl ester;
II-18 7-(6,6-Dimethyl-7-oxo-7-phenyl-heptane-1-sulfinyl)-2,2-dimethyl-1-phenyl-heptan-1-one;
II-19 8-(6,6-Dimethyl-7-oxo-8-phenyl-octane-1-sulfinyl)-3,3-dimethyl-1-phenyl-octan-2-one;
II-20 2-Methyl-7-(6-methyl-6-sulfo-heptane-1-sulfinyl)-heptane-2-sulfonic acid;
II-21 Phosphoric acid mono-[1,1-dimethyl-6-(6-methyl-6-phosphonooxy-heptane-1-sulfinyl)-hexyl]ester;
II-22 7-(7-Hydroxy-5,5-dimethyl-heptane-1-sulfinyl)-3,3-dimethyl-heptan-1-ol;
II-23 7-(7-Hydroxy-5,5-dimethyl-heptane-1-sulfinyl)-3,3-dimethyl-heptanoic acid;
II-24 7-(6-Carboxy-5,5-dimethyl-hexane-1-sulfinyl)-3,3-dimethyl-heptanoic acid;
II-25 6-(6-Hydroxy-4,4-dimethyl-hexane-1-sulfinyl)-3,3-dimethyl-hexan-1-ol;
II-26 6-(6-Hydroxy-4,4-dimethyl-hexane-1-sulfinyl)-3,3-dimethyl-hexanoic acid;
II-27 6-(5-Carboxy-4,4-dimethyl-pentane-1-sulfinyl)-3,3-dimethyl-hexanoic acid;
II-28 I-28-8-(8-Hydroxy-6,6-dimethyl-octane-1-sulfinyl)-3,3-dimethyl-octan-1-ol;
II-29 8-(8-Hydroxy-6,6-dimethyl-octane-1-sulfinyl)-3,3-dimethyl-octanoic acid;
II-30 8-(7-Carboxy-6,6-dimethyl-heptane-1-sulfinyl)-3,3-dimethyl-octanoic acid;
II-31 8-(8-Hydroxy-5,5-dimethyl-octane-1-sulfinyl)-4,4-dimethyl-octan-1-ol;
II-32 8-(8-Hydroxy-5,5-dimethyl-octane-1-sulfinyl)-4,4-dimethyl-octanoic acid;
II-33 8-(7-Carboxy-5,5-dimethyl-heptane-1-sulfinyl)-4,4-dimethyl-octanoic acid;
II-34 7-(7-Hydroxy-4,4-dimethyl-heptane-1-sulfinyl)-4,4-dimethyl-heptan-1-ol;
II-35 7-(7-Hydroxy-4,4-dimethyl-heptane-1-sulfinyl)-4,4-dimethyl-heptanoic acid;
II-36 7-(6-Carboxy-4,4-dimethyl-hexane-1-sulfinyl)-4,4-dimethyl-heptanoic acid;
II-37 9-(9-Hydroxy-6,6-dimethyl-nonane-1-sulfinyl)-4,4-dimethyl-nonan-1-ol;
II-38 9-(9-Hydroxy-6,6-dimethyl-nonane-1-sulfinyl)-4,4-dimethyl-nonanoic acid;
II-39 9-(8-Carboxy-6,6-dimethyl-octane-1-sulfinyl)-4,4-dimethyl-nonanoic acid;
II-40 5-[1,1-Dimethyl-4-(4-{3,3a-dihydro-4,6-dioxo-2H-thieno[3,2-c]pyridin-5-yl}-4-ethyl-pentane-1-sulfinyl)-butyl]-3,3a-dihydro-2H-thieno[3,2-c]pyridine-4,6-dione;
II-41 5-[1,1-Dimethyl-4-(4-{3,3a-dihydro-4,6-dithioxo-2H-thieno [3,2-c]pyridin-5-yl}-4-methyl-pentane-1-sulfinyl)-butyl]-3,3a-dihydro-2H-thieno[3,2-c]pyridine-4,6-dithione;
II-42 5-(4-Cyanocarbamoyl-4-methyl-pentane-1-sulfinyl)-2,2-dimethyl-pentanoic acid cyanimide;
II-43 Phosphoramidic acid mono-{4-[4-(amino-hydroxy-phosphoryloxy)-4-methyl-entane-1-sulfinyl]-1,1-dimethyl-butyl}ester;
II-44 4-(Amino-hydroxy-phosphoryloxy)-4-methyl-1-(4-[amino-hydroxy-phosphoryloxy]-4-methyl-pentane-1-sulfinyl)-pentane;
II-45 5-[1,1-Dimethyl-5-(5-{3,3a-dihydro-4,6-dioxo-2H-thieno[3,2-c]pyridin-5-yl}-5-methyl-hexane-1-sulfinyl)-pentyl]-3,3a-dihydro-2H-thieno[3,2-c]pyridine-4,6-dione;
II-46 5-[1,1-Dimethyl-5-(5-{3,3a-dihydro-4,6-dithioxo-2H-thieno[3,2-c]pyridin-5-yl}-5-methyl-hexane-1-sulfinyl)-pentyl]-3,3a-dihydro-2H-thieno[3,2-c]pyridine-4,6-dithione;
II-47 6-(5-Cyanocarbamoyl-5-methyl-hexylsulfanyl)-2,2-dimethyl-hexanoic acid cyanimide;
II-48 Phosphoramidic acid mono-{5-[5-(amino-hydroxy-phosphoryloxy)-5-methyl-hexane-1-sulfinyl]-1,1-dimethyl-pentyl}ester
II-49 5-(Amino-hydroxy-phosphoryloxy)-5-methyl-1-([5-amino-hydroxy-phosphoryloxy]-5-methyl-hexane-1-sulfinyl)-hexane;
II-50 1-[1,1-Dimethyl-5-(5-methyl-5-tetrazol-1-yl-hexane-1-sulfinyl)-pentyl]-1H-tetrazole;
II-51 5-[1,1-Dimethyl-5-(5-methyl-5-tetrazol-5-yl-hexane-1-sulfinyl)-pentyl]-1H-tetrazole;
II-52 5-[1,1-Dimethyl-5-(5-{isoxazol-3-5-yl}-5-methyl-hexane-1-sulfinyl)-pentyl]-isoxazol-3-ol;
II-53 4-[1,1-Dimethyl-5-(5-{isoxazol-3-4-yl}-5-methyl-hexane-1-sulfinyl)-pentyl]-isoxazol-3-ol;
II-54 4-[1,1-Dimethyl-5-(5-{2-oxo-oxetan-4-yl}-5-methyl-hexane-1-sulfinyl)-pentyl]-oxetan-2-one;
II-55 3-[1,1-Dimethyl-5-(5-{2-oxo-oxetan-3-yl}-5-methyl-hexane-1-sulfinyl)-pentyl]-oxetan-2-one;
II-56 5-[1,1-Dimethyl-5-(5-(2-oxo-dihydro-furan-5-yl}-5-methyl-hexane-1-sulfinyl)-pentyl]-dihydro-furan-2-one;
II-57 3-[1,1-Dimethyl-5-(5-(2-oxo-dihydro-furan-3-yl}-5-methyl-hexane-1-sulfinyl)-pentyl]-dihydro-furan-2-one;
II-58 4-[1,1-Dimethyl-5-(5-(2-oxo-dihydro-furan-4-yl}-5-methyl-hexane-1-sulfinyl)-pentyl]-dihydro-furan-2-one;
II-59 2-[1,1-Dimethyl-5-{tetrahydro-pyran-2-oxy}-5-methyl-hexane-1-sulfinyl)-pentyloxy]-tetrahydro-pyran;
II-60 (2-{5-[5-(4-Carboxymethyl-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-5-methyl-hexane-1-sulfinyl]-1,1-dimethyl-pentyl}-4-hydroxy-6-oxo-tetrahydro-pyran-4-yl)-acetic acid;
IIa-1 7-(7-Hydroxy-6-methyl-6-phenyl-heptane-1-sulfinyl)-2-methyl-2-phenyl-heptan-1-ol;
IIa-2 7-(7-Hydroxy-6-methyl-6-phenyl-heptane-1-sulfinyl)-2-methyl-2-phenyl-heptanoic acid;
IIa-3 7-(6-Carboxy-6-phenyl-heptane-1-sulfinyl)-2-methyl-2-phenyl-heptanoic acid;
IIa-4 6-(6-Hydroxy-5-methyl-5-phenyl-hexane-1-sulfinyl)-2-methyl-2-phenyl-hexan-1-ol;
IIa-5 6-(6-Hydroxy-5-methyl-5-phenyl-hexane-1-sulfinyl)-2-methyl-2-phenyl-hexanoic acid;
IIa-6 6-(5-Carboxy-5-phenyl-hexane-1-sulfinyl)-2-methyl-2-phenyl-hexanoic acid;
IIa-7 5-(5-Hydroxy-4-methyl-4-phenyl-pentane-1-sulfinyl)-2-methyl-2-phenyl-pentan-1-ol;
IIa-8 5-(5-Hydroxy-4-methyl-4-phenyl-pentane-1-sulfinyl)-2-methyl-2-phenyl-pentanoic acid;
IIa-9 5-(4-Carboxy-4-phenyl-pentane-1-sulfinyl)-2-methyl-2-phenyl-pentanoic acid;
IIa-10 2-Methyl-7-(6-methyl-7-oxo-6-phenyl-heptane-1-sulfinyl)-2-phenyl-heptanal;
IIa-11 7-(6-Methoxycarbonyl-6-phenyl-heptane-1-sulfinyl)-2-methyl-2-phenyl-heptanoic acid methyl ester;
IIa-12 2-Methyl-7-(6-methyl-7-oxo-6,7-diphenyl-heptane-1-sulfinyl)-1,2-diphenyl-heptan-1-one;
IIa-13 3-Methyl-8-(6-methyl-7-oxo-6,8-diphenyl-octane-1-sulfinyl)-1,3-diphenyl-octan-2-one;
IIa-14 2-Phenyl-7-(6-phenyl-6-sulfo-heptane-1-sulfinyl)-heptane-2-sulfonic acid;
IIa-15 Phosphoric acid mono-[1-methyl-1-phenyl-6-(6-phenyl-6-phosphonooxy-heptane-1-sulfinyl)-hexyl]ester;
IIa-16 8-(8-Hydroxy-6-methyl-6-phenyl-octane-1-sulfinyl)-3-methyl-3-phenyl-octan-1-ol;
IIa-17 8-(8-Hydroxy-6-methyl-6-phenyl-octane-1-sulfinyl)-3-methyl-3-phenyl-octanoic acid;
IIa-18 8-(7-Carboxy-6-methyl-6-phenyl-heptane-1-sulfinyl)-3-methyl-3-phenyl-octanoic acid;
IIa-19 7-(7-Hydroxy-5-methyl-5-phenyl-heptane-1-sulfinyl)-3-methyl-3-phenyl-heptan-1-ol;
IIa-20 7-(7-Hydroxy-5-methyl-5-phenyl-heptane-1-sulfinyl)-3-methyl-3-phenyl-heptanoic acid;
IIa-21 7-(6-Carboxy-5-methyl-5-phenyl-hexane-1-sulfinyl)-3-methyl-3-phenyl-heptanoic acid;
IIa-22 6-(6-Hydroxy-4-methyl-4-phenyl-hexane-1-sulfinyl)-3-methyl-3-phenyl-hexan-1-ol;
IIa-23 6-(6-Hydroxy-4-methyl-4-phenyl-hexane-1-sulfinyl)-3-methyl-3-phenyl-hexanoic acid;
IIa-24 6-(5-Carboxy-4-methyl-4-phenyl-pentane-1-sulfinyl)-3-methyl-3-phenyl-hexanoic acid;
IIa-25 6-(6-Hydroxy-4-methyl-4-phenyl-hexane-1-sulfinyl)-3-methyl-3-phenyl-hexanoic acid;
IIa-26 6-(5-Carboxy-4-methyl-4-phenyl-pentane-sulfinyl)-3-methyl-3-phenyl-hexanoic acid;
IIa-27 9-(9-Hydroxy-6-methyl-6-phenyl-nonane-1-sulfinyl)-4-methyl-4-phenyl-nonan-1-ol;
IIa-28 9-(9-Hydroxy-6-methyl-6-phenyl-nonane-1-sulfinyl)-4-methyl-4-phenyl-nonanoic acid;
IIa-29 9-(8-Carboxy-6-methyl-6-phenyl-octane-1-sulfinyl)-4-methyl-4-phenyl-nonanoic acid;
IIa-30 8-(8-Hydroxy-5-methyl-5-phenyl-octane-1-sulfinyl)-4-methyl-4-phenyl-octan-1-ol;
IIa-31 8-(8-Hydroxy-5-methyl-5-phenyl-octane-1-sulfinyl)-4-methyl-4-phenyl-octanoic acid;
IIa-32 8-(7-Carboxy-5-methyl-5-phenyl-heptane-1-sulfinyl)-4-methyl-4-phenyl-octanoic acid;
IIa-33 7-(7-Hydroxy-4-methyl-4-phenyl-heptane-1-sulfinyl)-4-methyl-4-phenyl-heptan-1-ol;
IIa-34 7-(7-Hydroxy-4-methyl-4-phenyl-heptane-1-sulfinyl)-4-methyl-4-phenyl-heptanoic acid;
IIa-35 7-(6-Carboxy-4-methyl-4-phenyl-hexane-1-sulfinyl)-4-methyl-4-phenyl-heptanoic acid;
IIa-36 5-[1-Methyl-1-phenyl-5-(5-phenyl-5-{3,3a-dihydro-4,6-dioxo-2H-thieno[3,2-c]pyridin-5-yl}-hexane-1-sulfinyl)-pentyl]-3,3a-dihydro-2H-thieno[3,2-c]pyridine-4,6-dione;
IIa-37 5-[1-Methyl-1-phenyl-5-(5-phenyl-5-{3,3a-dihydro-4,6-dithioxo-2H-thieno[3,2-c]pyridin-5-yl}-hexane-1-sulfinyl)-pentyl]-3,3a-dihydro-2H-thieno[3,2-c]pyridine-4,6-dithione;
IIa-38 6-(5-Cyanocarbamoyl-5-phenyl-hexane-1-sulfinyl)-2-methyl-2-phenyl-hexanoic acid cyanimide;
IIa-39 Phosphoramidic acid mono-{5-[5-(amino-hydroxy-phosphoryloxy)-5-phenyl-hexane-1-sulfinyl]-1-methyl-1-phenyl-pentyl}ester;
IIa-40 1-(5-[Amino-hydroxy-phosphoryloxy]-5-phenyl-hexane-1-sulfinyl)-5-[amino-hydroxy-phosphoryloxy]-5-phenyhexane;
IIa-41 1-[1-Methyl-1-phenyl-5-(5-phenyl-5-{tetrazol-1-yl}-hexane-1-sulfinyl)-pentyl]-1H-tetrazole;
IIa-42 5-[1-Methyl-1-phenyl-5-(5-phenyl-5-{tetrazol-5-yl}-hexane-1-sulfinyl)-pentyl]-1H-tetrazole;
IIa-43 5-[1-Methyl-1-phenyl-5-(5-{3-hydroxy-isoxazol-5-yl}-5-phenyl-hexane-1-sulfinyl)-pentyl]-isoxazol-3-ol;
IIa-44 4-[1-Methyl-1-phenyl-5-(5-{3-hydroxy-isoxazol-4-yl}-5-phenyl-hexane-1-sulfinyl)-pentyl]-isoxazol-3-ol;
IIa-45 2-[1-Methyl-1-phenyl-5-(5-{2-hydroxy-tetrahydro-pyranoxy}-5-phenyl-hexane-1-sulfinyl)-pentyloxy]-tetrahydro-pyran;
IIa-46 5-[1-Methyl-1-phenyl-5-(5-{2-oxo-dihydro-furan-5-yl}-5-phenyl-hexane-1-sulfinyl)-pentyl]-dihydro-furan-2-one;
IIa-47 4-[1-Methyl-1-phenyl-5-(5-{2-oxo-oxetan-4-yl}-5-phenyl-hexane-1-sulfinyl)-pentyl]-oxetan-2-one;
IIa-48 4-[1-Methyl-1-phenyl-5-(5-{2-oxo-dihydro-furan-4-yl}-5-phenyl-hexane-1-sulfinyl)-pentyl]-dihydro-furan-2-one;
IIa-49 3-[1-Methyl-1-phenyl-5-(5-{2-oxo-dihydro-furan-3-yl}-5-phenyl-hexane-1-sulfinyl)-pentyl]-dihydro-furan-2-one;
IIa-50 (2-{5-[5-(4-Carboxymethyl-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-5-phenyl-hexane-1-sulfinyl]-1-methyl-1-phenyl-pentyl}-4-hydroxy-6-oxo-tetrahydro-pyran-4-yl)-acetic;
III-1-(6-{3-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-1,4-dioxo-1,4-dihydro-4H-thiopyran-2-yl]-propyl}-1,4-dioxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentan-1-ol;
III-2 5-(6-{3-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-1,4-dioxo-1,4-dihydro-4H-thiopyran-2-yl]-propyl}-1,4-dioxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid;
III-3 5-(6-{3-[6-(4-Carboxy-4-methyl-pentyl)-1,4-dioxo-l ,4-dihydro-4H-thiopyran-2-yl]-propyl}-1,4-dioxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid;
III-4 5-(6-{3-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl]-propyl}-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentan-1-ol;
III-5 5-(6-{3-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl]-propyl}-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid;
III-6 5-(6-{3-[6-(4-Carboxy-4-methyl-pentyl)-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl]-propyl}-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid;
III-7 6-(6-{3-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-4-oxo-4H-thiopyran-2-yl]-propyl}-4-oxo-4H-thiopyran-2-yl)-2,2-dimethyl-hexan-1-ol;
III-8 6-(6-{3-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-1,4-dioxo-1,4-dihydro-4H-thiopyran-2-yl]-propyl}-1,4-dioxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid;
III-9 6-(6-{3-[6-(5-Carboxy-5-methyl-hexyl)-1,4-dioxo-1,4-dihydro-4H-thiopyran-2-yl]-propyl}-1,4-dioxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid;
III-10 6-(6-{3-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-4,4-dimethyl-4H-thiopyran-2-yl]-propyl}-4,4-dimethyl4H-thiopyran-2-yl)-2,2-dimethyl-hexan-1-ol;
III-11 6-(6-{3-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl]-propyl}-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexan-1-ol;
III-12 6-(6-{3-[6-(5-Carboxy-5-methyl-hexyl)-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl]-propyl}-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid;
III-13 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-1-oxo-hexahydro-4H-thiopyran-2-yl]-vinyl}-1-oxo-hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexan-1-ol;
III-14 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-1-oxo-hexahydro-4H-thiopyran-2-yl]-vinyl}-1-oxo-hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid;
III-15 6-(6-{2-[6-(5-Carboxy-5-methyl-hexyl)-1-oxo-hexahydro-4H-thiopyran-2-yl]-vinyl}-1-oxo-hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid;
III-16 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-1,4-dioxo-4H-thiopyran-2-yl]-vinyl}-1,4-dioxo-4H-thiopyran-2-yl)-2,2-dimethyl-hexan-1-ol;
III-17 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-1,4-dioxo-1,4-dihydro-4H-thiopyran-2-yl]-vinyl}-1,4-dioxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid;
III-18 6-(6-{2-[6-(5-Carboxy-5-methyl-hexyl)-1,4-dioxo-1,4-dihydro-4H-thiopyran-2-yl]-vinyl}-1,4-dioxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid;
III-19 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl]-vinyl}-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexan-1-ol;
III-20 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl]-vinyl}-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid;
III-21 6-(6-{2-[6-(5-Carboxy-5-methyl-hexyl)-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl]-vinyl}-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid;
III-22 6-(6-{2-[6-(5-Carboxy-5-methyl-hexyl)-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl]-vinyl}-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid;
III-23 5-(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-1-oxo-hexahydro-4H-thiopyran-2-yl]-vinyl}-1-oxo-hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid;
III-24 5-(6-{2-[6-(4-Carboxy-4-methyl-pentyl)-1-oxo-hexahydro-4H-thiopyran-2-yl]-vinyl}-1-oxo-hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid;
III-25 5-(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-1,4-dioxo-4H-thiopyran-2-yl]-vinyl}-1,4-dioxo-4H-thiopyran-2-yl)-2,2-dimethyl-pentan-1-ol;
III-26 5-(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-1,4-dioxo-1,4-dihydro-4H-thiopyran-2-yl]-vinyl}-1,4-dioxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid;
III-27 5-(6-{2-[6-(4-Carboxy-4-methyl-pentyl)-1,4-dioxo-1,4-dihydro-4H-thiopyran-2-yl]-vinyl}-1,4-dioxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid;
III-28 5-(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl]-vinyl}-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentan-1-ol;
III-29 5-(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl]-vinyl}-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid;
III-30 5-(6-{2-[6-(4-Carboxy-4-methyl-pentyl)-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl]-vinyl}-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid;
III-31 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-1,4-dioxo-4H-thiopyran-2-yl]-ethyl}-1,4-dioxo-4H-thiopyran-2-yl)-2,2-dimethyl-hexan-1-ol;
III-32 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-1,4-dioxo-1,4-dihydro-4H-thiopyran-2-yl]-ethyl}-1,4-dioxo-,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid;
III-33 6-(6-{2-[6-(5-Carboxy-5-methyl-hexyl)-1,4-dioxo-1,4-dihydro-4H-thiopyran-2-yl]-ethyl}-1,4-dioxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid;
III-34 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl]-ethyl}-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexan-1-ol;
III-35 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl]-ethyl}-4,4-dimethyl-oxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid;
III-36 6-(6-{2-[6-(5-Carboxy-5-methyl-hexyl)-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl]-ethyl}-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid;
III-37 5-(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-1,4-dioxo-4H-thiopyran-2-yl]-ethyl}-1,4-dioxo-4H-thiopyran-2-yl)-2,2-dimethyl-pentan-1-ol;
III-38 5-(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-1,4-dioxo-1,4-dihydro-4H-thiopyran-2-yl]-ethyl}-1,4-dioxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid;
III-39 5-(6-{2-[6-(4-Carboxy-4-methyl-pentyl)-1,4-dioxo-1,4-dihydro-4H-thiopyran-2-yl]-ethyl}-1,4-dioxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid;
III-40 5-(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-4,4-dimethyl-1-oxo-1,4-dihydro-114-thiopyran-2-yl]-ethyl}-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentan-1-ol;
III-41 5-(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-4,4-dimethyl-1-oxo-1,4-dihydro-114-thiopyran-2-yl]-ethyl}-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid;
III-42 5-(6-{2-[6-(4-Carboxy-4-methyl-pentyl)-4,4-dimethyl-1-oxo-1,4-dihydro-114-thiopyran-2-yl]-ethyl}-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid;
III-43 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-1-oxo-hexahydro-4H-thiopyran-2-yl]-phenyl}-1-oxo-hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexan-1-ol;
III-44 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-1-oxo-hexahydro-4H-thiopyran-2-yl]-phenyl}-1-oxo-hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid;
III-45 6-(6-{2-[6-(5-Carboxy-5-methyl-hexyl)-1-oxo-hexahydro-4H-thiopyran-2-yl]-phenyl}-oxo-hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid;
III-46 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-1,4-dioxo-4H-thiopyran-2-yl]-phenyl}-1,4-dioxo-4H-thiopyran-2-yl)-2,2-dimethyl-hexan-1-ol;
III-47 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-1,4-dioxo-1,4-dihydro-4H-thiopyran-2-yl]-phenyl}-1,4-dioxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid;
III-48 6-(6-{2-[6-(5-Carboxy-5-methyl-hexyl)-1,4-dioxo-1,4-dihydro-4H-thiopyran-2-yl]-phenyl}-1,4-dioxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid;
III-49 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl]-phenyl}-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexan-1-ol;
III-50 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl]-phenyl}-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid;
III-51 6-(6-{2-[6-(5-Carboxy-5-methyl-hexyl)-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl]-phenyl}-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid;
III-52 5-(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-1-oxo-hexahydro-4H-thiopyran-2-yl]-phenyl}-1-oxo-hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentan-1-ol;
III-53 5-(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-1-oxo-hexahydro-4H-thiopyran-2-yl]-phenyl}-1-oxo-hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid;
III-54 5-(6-{2-[6-(4-Carboxy-4-methyl-pentyl)-1-oxo-hexahydro-4H-thiopyran-2-yl]-phenyl}-1-oxo-hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid;
III-55 5-(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-1-oxo-1,4-dioxo-4H-thiopyran-2-yl]-phenyl}-1-oxo-1,4-dioxo-4H-thiopyran-2-yl)-2,2-dimethyl-pentan-1-ol;
III-56 5-(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-1,4-dioxo-1,4-dihydro-4H-thiopyran-2-yl]-phenyl}-1,4-dioxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid;
III-57 5-(6-{2-[6-(4-Carboxy-4-methyl-pentyl)-1,4-dioxo-1,4-dihydro-4H-thiopyran-2-yl]-phenyl}-1,4-dioxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid;
III-58 5-(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl]-phenyl}-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentan-1-ol;
III-59 5-(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl]-phenyl}-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid;
III-60 5-(6-{2-[6-(4-Carboxy-4-methyl-pentyl)-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl]-phenyl}-4,4-dimethyl-1-oxo-1,4-dihydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid;
III-61 5-(5-{3-[5-(5-Hydroxy-4,4-dimethyl-pentyl)-1-oxo-1H-4H-thiophen-2-yl]-propyl}-1-oxo-1H-4H-thiophen-2-yl)-2,2-dimethyl-pentan-1-ol;
III-62 5-(5-{3-[5-(5-Hydroxy-4,4-dimethyl-pentyl)-1-oxo-1H-4H-thiophen-2-yl]-propyl}-1-oxo-1H-4H-thiophen-2-yl)-2,2-dimethyl-pentanoic acid;
III-63 5-(5-{3-[5-(4-Carboxy-4-methyl-pentyl)-1-oxo-1H-4H-thiophen-2-yl]-propyl}-1-oxo-1H-4H-thiophen-2-yl)-2,2-dimethyl-pentanoic acid;
III-64 6-(5-{3-[5-(6-Hydroxy-5,5-dimethyl-hexyl)-1-oxo-1H-4H-thiophen-2-yl]-propyl}-1-oxo-1H-4H-thiophen-2-yl)-2,2-dimethyl-hexan-1-ol;
III-65 6-(5-{3-[5-(6-Hydroxy-5,5-dimethyl-hexyl)-1-oxo-1H-4H-thiophen-2-yl]-propyl}-1-oxo-1H-4H-thiophen-2-yl)-2,2-dimethyl-hexanoic acid;
III-66 6-(5-{3-[5-(5-Carboxy-5-methyl-hexyl)-1-oxo-1H-4H-thiophen-2-yl]-propyl}-1-oxo-1H-4H-thiophen-2-yl)-2,2-dimethyl-hexanoic acid;
III-67 6-(5-{2-[5-(6-Hydroxy-5,5-dimethyl-hexyl)-1-oxo-tetrahydro-4H-thiophen-2-yl]-vinyl}-1-oxo-tetrahydro-4H-thiophen-2-yl)-2,2-dimethyl-hexan-1-ol;
III-68 6-(5-{2-[5-(6-Hydroxy-5,5-dimethyl-hexyl)-1-oxo-tetrahydro-4H-thiophen-2-yl]-vinyl}-oxo-tetrahydro-4H-thiophen-2-yl)-2,2-dimethyl-hexanoic acid;
III-69 6-(5-{2-[5-(6-Hydroperoxy-5,5-dimethyl-hexyl)-1-oxo-tetrahydro-4H-thiophen-2-yl]-vinyl}-1-oxo-tetrahydro-4H-thiophen-2-yl)-2,2-dimethyl-hexanoic acid;
III-70 6-(5-{2-[5-(6-Hydroxy-5,5-dimethyl-hexyl)-1-oxo-1H-4H-thiophen-2-yl]-vinyl}-1-oxo-1H-4H-thiophen-2-yl)-2,2-dimethyl-hexan-1-ol;
III-71 6-(5-{2-[5-(6-Hydroxy-5,5-dimethyl-hexyl)-1-oxo-1H-4H-thiophen-2-yl]-vinyl}-1-oxo-1H-4H-thiophen-2-yl)-2,2-dimethyl-hexanoic acid;
III-72 6-(5-{2-[5-(5-Carboxy-5-methyl-hexyl)-1-oxo-1H-4H-thiophen-2-yl]-vinyl}-1-oxo-1H-4H-thiophen-2-yl)-2,2-dimethyl-hexanoic acid;
III-73 5-(5-{2-[5-(5-Hydroxy-4,4-dimethyl-pentyl)-1-oxo-tetrahydro-4H-thiophen-2-yl]-vinyl}-1-oxo-tetrahydro-4H-thiophen-2-yl)-2,2-dimethyl-pentan-1-ol;
III-74 5-(5-{2-[5-(5-Hydroxy-4,4-dimethyl-pentyl)-1-oxo-tetrahydro-4H-thiophen-2-yl]-vinyl}-1-oxo-tetrahydro-4H-thiophen-2-yl)-2,2-dimethyl-pentanoic acid;
III-75 5-(5-{2-[5-(4-Carboxy-4-methyl-pentyl)-1-oxo-tetrahydro-4H-thiophen-2-yl]-vinyl}-1-oxo-tetrahydro-4H-thiophen-2-yl)-2,2-dimethyl-pentanoic acid;
III-76 5-(5-{2-[5-(5-Hydroxy-4,4-dimethyl-pentyl)-1-oxo-1H-4H-thiophen-2-yl]-vinyl}-1-oxo-1H-4H-thiophen-2-yl)-2,2-dimethyl-pentan-1-ol;
III-77 5-(5-{2-[5-(5-Hydroxy-4,4-dimethyl-pentyl)-1-oxo-1H-4H-thiophen-2-yl]-vinyl}-1-oxo-1H-4H-thiophen-2-yl)-2,2-dimethyl-pentanoic acid;
III-78 5-(5-{2-[5-(4-Carboxy-4-methyl-pentyl)-1-oxo-1H-4H-thiophen-2-yl]-vinyl}-1-oxo-1H-4H-thiophen-2-yl)-2,2-dimethyl-pentanoic acid;
III-79 6-(5-{2-[5-(6-Hydroxy-5,5-dimethyl-hexyl)-1-oxo-tetrahydro-4H-thiophen-2-yl]-vinyl}-1-oxo-tetrahydro-4H-thiophen-2-yl)-2,2-dimethyl-hexan-1-ol;
III-80 6-(5-{2-[5-(6-Hydroxy-5,5-dimethyl-hexyl)-1-oxo-tetrahydro-4H-thiophen-2-yl]-vinyl}-1-oxo-tetrahydro-4H-thiophen-2-yl)-2,2-dimethyl-hexanoic acid;
III-81 6-(5-{2-[5-(5-Carboxy-5-methyl-hexyl)-1-oxo-tetrahydro-4H-thiophen-2-yl]-vinyl}-1-oxo-tetrahydro-4H-thiophen-2-yl)-2,2-dimethyl-hexanoic acid;
III-82 6-(5-{2-[5-(6-Hydroxy-5,5-dimethyl-hexyl)-1-oxo-1H-4H-thiophen-2-yl]-vinyl}-1-oxo-1H-4H-thiophen-2-yl)-2,2-dimethyl-hexan-1-ol;
III-83 6-(5-{2-[5-(6-Hydroxy-5,5-dimethyl-hexyl)-1-oxo-1H-4H-thiophen-2-yl]-vinyl}-1-oxo-1H-4H-thiophen-2-yl)-2,2-dimethyl-hexanoic acid;
III-84 6-(5-{2-[5-(5-Carboxy-5-methyl-hexyl)-1-oxo-1H-4H-thiophen-2-yl]-vinyl}-1-oxo-1H-4H-thiophen-2-yl)-2,2-dimethyl-hexanoic acid;
III-85 5-(5-{2-[5-(5-Hydroxy-4,4-dimethyl-pentyl)-1-oxo-1H-4H-thiophen-2-yl]-ethyl}-1-oxo-1H-4H-thiophen-2-yl)-2,2-dimethyl-pentan-1-ol;
III-86 5-(5-{2-[5-(5-Hydroxy-4,4-dimethyl-pentyl)-1-oxo-1H-4H-thiophen-2-yl]-ethyl}-1-oxo-1H-4H-thiophen-2-yl)-2,2-dimethyl-pentanoic acid;
III-87 5-(5-{2-[5-(4-Carboxy-4-methyl-pentyl)-1-oxo-1H-4H-thiophen-2-yl]-ethyl}-1-oxo-1H-4H-thiophen-2-yl)-2,2-dimethyl-pentanoic acid;
IIIa-1 5-(6-{3-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-tetrahydro-thiopyran-2-yl]-propyl}-tetrahydro-thiopyran-2-yl)-2,2-dimethyl-pentan-1-ol;
IIIa-2 5-(6-{3-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-tetrahydro-thiopyran-2-yl]-propyl}-tetrahydro-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid;
IIIa-3 5-(6-{3-[6-(4-Carboxy-4-methyl-pentyl)-tetrahydro-thiopyran-2-yl]-propyl}-tetrahydro-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid;
IIIa-4 6-(6-{3-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-tetrahydro-thiopyran-2-yl]-propyl}-tetrahydro-thiopyran-2-yl)-2,2-dimethyl-hexan-1-ol;
IIIa-5 6-(6-{3-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-tetrahydro-thiopyran-2-yl]-propyl}-tetrahydro-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid;
IIIa-6 6-(6-{3-[6-(5-Carboxy-5-methyl-hexyl)-tetrahydro-thiopyran-2-yl]-propyl}-tetrahydro-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid;
IIIa-7 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-1-oxo-hexahydro-4H-thiopyran-2-yl]-ethyl}-1-oxo-hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexan-1-ol;
IIIa-8 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-1-oxo-hexahydro-4H-thiopyran-2-yl]-ethyl}-1-oxo-hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid
IIIa-9 6-(6-{2-[6-(5-Carboxy-5-methyl-hexyl)-1-oxo-hexahydro-4H-thiopyran-2-yl]-ethyl}-1-oxo-hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid;
IIIa-10 5-(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-1-oxo-hexahydro-4H-thiopyran-2-yl]-ethyl}-1-oxo-hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentan-1-ol;
IIIa-11 5-(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-1-oxo-hexahydro-4H-thiopyran-2-yl]-ethyl}-1-oxo-hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid;
IIIa-12 5-(6-{2-[6-(4-Carboxy-4-methyl-pentyl)-1-oxo-hexahydro-4H-thiopyran-2-yl]-ethyl}-1-oxo-hexahydro-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid;
IIIa-13 5-(5-{3-[5-(5-Hydroxy-4,4-dimethyl-pentyl)-1-oxo-tetrahydro-4H-thiophen-2-yl]-propyl}-1-oxo-tetrahydro-4H-thiophen-2-yl)-2,2-dimethyl-pentan-1-ol;
IIIa-14 5-(5-{3-[5-(5-Hydroxy-4,4-dimethyl-pentyl)-1-oxo-tetrahydro-4H-thiophen-2-yl]-propyl}-1-oxo-tetrahydro-4H-thiophen-2-yl)-2,2-dimethyl-pentanoic acid;
IIIa-15 5-(5-{3-[5-(4-Carboxy-4-methyl-pentyl)-1-oxo-tetrahydro-4H-thiophen-2-yl]-propyl}-1-oxo-tetrahydro-4H-thiophen-2-yl)-2,2-dimethyl-pentanoic acid;
IIIa-16 6-(5-{3-[5-(6-Hydroxy-5,5-dimethyl-hexyl)-1-oxo-tetrahydro-4H-thiophen-2-yl]-propyl}-1-oxo-tetrahydro-4H-thiophen-2-yl)-2,2-dimethyl-hexan-1-ol;
IIIa-17 6-(5-{3-[5-(6-Hydroxy-5,5-dimethyl-hexyl)-1-oxo-tetrahydro-4H-thiophen-2-yl]-propyl}-1-oxo-tetrahydro-4H-thiophen-2-yl)-2,2-dimethyl-hexanoic acid
IIIa-18 6-(5-{3-[5-(5-Carboxy-5-methyl-hexyl)-1-oxo-tetrahydro-4H-thiophen-2-yl]-propyl}-1-oxo-tetrahydro-4H-thiophen-2-yl)-2,2-dimethyl-hexanoic acid;
IIIa-19 5-(5-{2-[5-(5-Hydroxy-4,4-dimethyl-pentyl)-1-oxo-tetrahydro-4H-thiophen-2-yl]-ethyl}-1-oxo-tetrahydro-4H-thiophen-2-yl)-2,2-dimethyl-pentan-1-ol;
IIIa-20 5-(5-{2-[5-(5-Hydroxy-4,4-dimethyl-pentyl)-1-oxo-tetrahydro-4H-thiophen-2-yl]-ethyl}-1-oxo-tetrahydro-4H-thiophen-2-yl)-2,2-dimethyl-pentanoic acid;
or
IIIa-21 5-(5-{2-[5-(4-Carboxy-4-methyl-pentyl)-1-oxo-tetrahydro-4H-thiophen-2-yl]-ethyl}-1-oxo-tetrahydro-4H-thiophen-2-yl)-2,2-dimethyl-pentanoic acid;
or a pharmaceutically acceptable salt, hydrate, solvate, clathrate, stereoisomer, diastereomer, geometric isomer or mixtures thereof.

445 more elements

Dependencies are inferred from the claim text.

Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses

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Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses

Life of this patent

Abstract

Claims9