Transgenic animal models for cardiac hypertrophy and methods of use thereof (treating)
AssigneesBoard of Regents, The University of Texas System, University of North Texas Health Science Center
InventorsStephen R. Grant, Eric N. Olson
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Abstract
Transgene constructs for generating transgenic animals, wherein the transgene encodes a gene product which modulates transcription of a hypertrophy-sensitive gene, are provided. Further provided are recombinant vectors comprising the transgenes of the invention. Further provided are transgenic animals generated using the transgene constructs. Further provided are enzyme-based, cell-based, and whole-animal-based assays for detecting substances having therapeutic activity toward cardiac hypertrophy. Further provided are compositions comprising substances which modulate levels of active product of a hypertrophy-sensitive gene. Further provided are methods of treating cardiac hypertrophy.
Claims9
A method of treating cardiac hypertrophy-induced dysfunction, comprising administering to a subject in need thereof an amount of a composition effective to diminish or reverse progression of the dysfunction, wherein the composition inhibits activity of calcineurin or calcium calmodulin dependent kinase IV (CaMKIV).
Dependencies are inferred from the claim text.