Gel composition and methods
AssigneeAlza Corporation
InventorsKevin J. Brodbeck, Ann T. Gaynor-Duarte, Theodore Tao-Ian Shen
Life of this patent
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Abstract
Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, compositions having burst indices of 8 or less for systemic applications and systems releasing 10% or less of the total dose of beneficial agent in the first 24 hours after implantation for local applications. The compositions include a biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.
Claims81
A method of systemically administering a beneficial agent to a subject which comprises implanting a system comprising a polylactide polymer;
- an effective plasticizing amount of a solvent comprising a lower alkyl or aralkyl ester of benzoic acid to form a gel with the polymer;
- and a beneficial agent;
- wherein said beneficial agent is dissolved or dispersed substantially throughout the gel.
A method of administering a beneficial agent to a subject which comprises implanting a system comprising a beneficial agent dissolved or dispersed substantially throughout a gel formed of a polylactide polymer and a solvent having a solubility in water of 7% or less, wherein said solvent is a lower alkyl or aralkyl ester of benzoic acid, and a solubility modulator of the beneficial agent.
A method of systemically administering a beneficial agent to a subject which comprises implanting a system comprising a poly(lactide-co-glycolide) copolymer;
- an effective plasticizing amount of a solvent comprising a lower alkyl or aralkyl ester of benzoic acid to form a gel with the polymer;
- and a beneficial agent;
- said beneficial agent dissolved or dispersed substantially throughout the gel.
A method of systemically administering a beneficial agent to a subject which comprises implanting a system comprising a beneficial agent dissolved or dispersed substantially throughout a gel formed of a polylactide polymer;
- an amount of a solvent comprising a lower alkyl or aralkyl ester of benzoic acid effective to form a viscous gel, having a viscosity of from about 1,000 poise to about 200,000 poise, with the polymer;
- and a beneficial agent.
A method of systemically administering a beneficial agent to a subject which comprises implanting a system comprising a beneficial agent dissolved or dispersed substantially throughout a gel formed of a poly(lactide-co-glycolide) copolymer;
- an amount of a solvent comprising a lower alkyl or aralkyl ester of benzoic acid effective to form a viscous gel, having a viscosity of from about 1,000 poise to about 200,000 poise, with the polymer;
- and a beneficial agent.
Dependencies are inferred from the claim text.