Therapeutic uses for mesenchymal stromal cells
AssigneeThe Children's Hospital of Philadelphia
InventorsGihan Tennekoon, Andrew J. Coyle, Judith Grinspan, Jackie S. Beesley
Life of this patent
Estimating the term…
Abstract
Human mesenchymal stromal cells can be induced to differentiate into oligodendrocytes and neurons, respectively. For these cell types, therefore, MSCs can be a therapeutic source, either in vitro or in vivo, in the context of treating pathologies of the central nervous system which are characterized by neuron loss, such as Parkinson's disease, Alzheimer's disease and stroke, as well as head trauma, or by dysfunction in ganglioside storage or demyelinization, such as Tay-Sachs disease, G1 gangliosidosis, metachromatic leukodystrophy, and multiple sclerosis.
Claims4
A method for differentiating a mesenchymal stromal cell into an oligodendrocyte precursor cell, comprising (i) providing a composition in vitro that consists essentially of said mesenchymal stromal cells and a physiologically compatible carrier, (ii) and culturing said cells in a medium comprising a neuroblastoma conditioned medium, wherein said culturing step provides oligodendrocyte precursor cells capable of differentiating into oligodendrocytes.
Dependencies are inferred from the claim text.