Cell paste comprising keratinocytes and fibroblasts
AssigneeModex Therapeutiques, S.A.
InventorsE. Edward Baetge, Thomas Hunziker, Alain Limat, Vincent Ronfard
Life of this patent
Estimating the term…
Abstract
The present invention provides the use and composition of matter of angiogenic or other growth factors expressed by combining various types and stages of differentiation of allogeneic human cell strains or lines in unencapsulated pastes (mixed with or applied to extracellular matrix material or synthetic biocompatible substances) to be temporarily applied to wounds or defects in the skin or other tissues for the restoration of blood supplying connective tissue to enable organ-specific cells to reestablish organ integrity as well as to inhibit excessive scar formation.
Claims3
A cell paste, comprising:
- a) one or more keratinocytes and fibroblasts that naturally secretes on or more biologically active molecules selected from the group consisting of GM-CSF, V GF, KGF, bFGF, TGFfβ admixed with
- b) an extracellular matrix or matrix material, wherein said extracellular matrix or matrix material is selected from the group consisting of collagens, alginate, alginate beads, agarose, fibrin, fibrin glue, blood plasma, fibrin beads, laminins, proteoglycans, fibronectins, chitosan, and heparin,
- c) wherein the cells are mitotically inactivated by irradiation, and;
- d) wherein the cells are allogeneic such that the resulting admixture forms a viscous cell paste.
Dependencies are inferred from the claim text.