Histone deacetylase, and uses therefor

An isolated polynucleotide, wherein said isolated polynucleotide is selected from the group consisting of:

• (i) a polynucleotide encoding a histone deacetylase (HDAC), wherein said histone deacetylase comprises a repression domain comprising an amino acid sequence set forth in amino acids 2-254 of SEQ ID NO:2, or conservative substitutions thereof,
• (ii) a fragment of at least 50 contiguous nucleotides of the polynucleotide of (i), and
• (iii) a full complement of (i) or (ii);
• wherein said histone deacetylase interacts in an mSin3A independent manner with Silencing Mediator for Retinoic and Thyroid receptors (SMRT), nuclear receptor co-repressor (N-CoR), or an isoform or peptide portion of SMRT or N-CoR.

An isolated polynucleotide, wherein said isolated polynucleotide is selected the group consisting of:

• (i) a polynucleotide encoding a histone deacetylase (HDAC), wherein said histone deacetylase comprises a repression domain comprising an amino acid sequence set forth in amino acids 241-533 of SEQ ID NO:2, or conservative substitutions thereof,
• (ii) a fragment of at least 50 contiguous nucleotides of the polynucleotide of (i), and
• (iii) a fill complement of (i) or (ii);
• wherein said histone deacetylase interacts in an mSin3A independent manner with Silencing Mediator for Retinoic and Thyroid receptors (SMRT), nuclear receptor co-repressor (N-CoR), or an isoform or peptide portion of SMRT or N-CoR.

An isolated polynucleotide, wherein said isolated polynucleotide is selected from the group consisting of:

• (i) a polynucleotide encoding a histone deacetylase (HDAC), wherein said histone deacetylase comprises a deacetylase domain comprising an amino acid sequence set forth in amino acids 506-938 of SEQ ID NO:2, or conservative substitutions thereof,
• (ii) a fragment of at least 50 contiguous nucleotides of the polynucleotide of (i), and
• (iii) a full complement of (i) or (ii);
• wherein said histone deacetylase interacts in an mSin3A independent manner with Silencing Mediator for Retinoic and Thyroid receptors (SMRT), nuclear receptor co-repressor (N-CoR), or an isoform or peptide portion of SMRT or N-CoR.