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US 6,673,559 B1Granted
Met proto-oncogene and a method for predicting breast cancer progression
AssigneeThe Government of the United States of America as represented by the Department of Health and Human Services
InventorsIlan Tsarfaty, James H. Resau, Iafa Keydar, Donna Faletto, George F. Vande Woude
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Abstract
A method for predicting breast tumor metastasis entails determining the amount of met protein in tumor tissue relative to normal breast duct tissue.
Claims4
A method for predicting the progression of a breast cancer comprising the steps of:
- (a) determining one or more of met DNA abundance, met mRNA abundance, or Met protein abundance in normal breast tissue and in tumor breast tissue and (b) comparing the abundance of said met DNA, met RNA or Met protein in normal breast tissue with said met DNA, met RNA or Met protein in tumor breast tissue, wherein said normal and tumor tissue is from the same breast, and wherein a higher abundance of met DNA, met RNA, or Met protein in said normal tissue than in said tumor tissue indicates a poor prognosis.
A method for predicting the progression of a breast cancer by determining Met protein abundance in normal breast tissue and in tumor breast tissue, comprising the steps of:
- a) contacting a section from a breast tumor with an antibody reagent specific for Met protein under antibody binding conditions, wherein said section contains normal breast tissue and tumor tissue;
- b) determining the binding of the reagent to Met protein in said normal tissue and said tumor tissue;
- and
- c) comparing said binding of said reagent to Met protein in said normal tissue with said binding in said tumor tissue;
- wherein, greater binding of said reagent to said normal than to said tumor tissue indicates a poor prognosis.
2 more elements
Dependencies are inferred from the claim text.