Methods of treatment of eye trauma and disorders

A method for treating decreased blood flow or nutrient supply to retinal tissue or optic nerve, or retinal ischemia or trauma, or optic nerve injury, comprising administering to a mammal in need of such treatment an effective amount of a compound of the following Formula II:

• wherein R, R′ and R″ are independently a C1-C8 alkyl group, a C2-C8 alkenyl group, C2-C8 alkynyl group, cycloalkyl group, cycloalkyl group substituted by one or more substituents, cycloalkenyl group, cycloalkenyl group substituted with one or more substituents, carbocyclic aryl group, carbocyclic aryl group substituted by one or more substituents, alkaryl group, alkaryl group substituted by one or more substituents, heterocyclic group, heterocyclic group substituted by one or more substituents, heteroaryl group, or a heteroaryl group substituted by one or more substituents;
• or a physiologically acceptable salt thereof;
• wherein said substituent is chloro, fluoro, bromo, iodo, C1-C8 alkyl, C1-C8 alkoxy, cyano, C3-C15 dialkylaminoalkyl, carboxy, carboxamido, C1-C8 alkylthio, allyl, aralkyl, alkaryl, C3-C6 cycloalkyl, aroyl, aralkoxy, C2-C8 acyl, aryl, heteroaryl, an aryl fused to a benzene ring, a heteroaryl fused to a benzene ring, C3-C6 heterocycloalkyl, a C3-C6 heterocycloalkyl ring fused to a benzene ring, C1-C8 alkylsulfonyl, arylthio, amino, C1-C8 alkylamino, C2-C15 dialkylamino, hydroxy, hydroxyalkyl, carbamoyl, C1-C8 N-alkylcarbamoyl, C2-C15 N,N′-dialkylcarbamoyl, nitro, azido or a C2-C15 dialkylsulfamoyl.