Genes expressed in C3A liver cell cultures treated with steroids
AssigneeIncyte Corporation
InventorsL. Michael Furness, Jenny L. Buchbinder
Life of this patent
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Abstract
The present invention relates to a combination comprising a plurality of cDNAs which are differentially expressed in human C3A liver cell cultures treated with steroids or synthetic steroid analogues and which may be used entirely or in part to detect metabolic and toxicological responses to treatment with steroids and steroid antagonists, to diagnose, to stage, to treat, or to monitor the treatment of a subject with an steroid responsive disorder.
Claims7
A combination comprising a plurality of cDNAs wherein the plurality of cDNAs are differentially expressed in response to steroid treatment and consist of the nucleic acid sequences of SEQ ID NOs:1-3, 5, 6, 8, 9, 11-14, 16-18, 20, 21, 23-34, 36, 38-40, 42-50, 52-63, 65, 66, 68-71, 73-75, 77-84, 86-111, 113-115, 117-126, 128-142, 145-160, 162-164, 166, 167, 169-172, 174-176, 178-186, 188-197, 199-202, 204-211, 213, 215, 217-228, 230-246, 248-251, 253-259, 261-266, 268-277, 279, 281, 283, 284, 286, 288-292, 294, 295, 297-300, 302-308, 310, 311, 313, 315-320, 322, 323, 325, 327-346, 348-350, 352-357, 359-368, 370-372, 374, 376, 378, 380-389, 391-400, 402, 403, 405-413, 415, 416, 418, 420, 422-426, 428, 429, 431-446, 448, 450-453, 455, 457, 459, 461, 463-466, 468-470, 472-478, 480-488, 490-492, 494-502, 504-506, 508-520, 522-526, 528-530, 532, 534, 535, 537-561, 563-565, 567, 569-575, 577, 579-581, 583, 585-589, 591-614, 616, 618, 619, 621, 623, 625, 627, 629-641, 643, 645-654, 656-663, 665-680, 682-698, 700-708, 710, 712-720, 722-725, 727-730, 732, 734, 735, 737-741, 743-754, 756, 758-768, 770-780, 782-786, 788-792, 794, 796-802, 804-806, 808, 809, 811-814, 816, 817, 819-829, 831, 833, 835, 836, 838-840, 842-888, 890-892, 894-908, 910, 912, 914-927, 929, 930, 932-937, 939-944, 946, 948-957, 959-964, 966-976, 978-988, 990-999, 1001-1008, 1010-1028, 1030-1034, 1036-1085, 1087-1096, 1098-1143 or a plurality of cDNAs consisting of the complements thereof.
Dependencies are inferred from the claim text.