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US 6,673,546 B2Granted
Genetic loci indicative of propensity for longevity and methods for identifying propensity for age-related disease
AssigneesChildren's Medical Center Corporation, Beth Israel Deaconess Medical Center, Inc.
InventorsThomas T. Perls, Louis Kunkel, Annibale A. Puca
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Abstract
This invention relates to genetic loci and methods for using polymorphic markers indicative of the propensity for longevity and the resistance to age-related disease. In particular, the invention defines a specified region of human chromosome 4 associated with exceptional longevity.
Claims8
A method for determining propensity for longevity in a patient, the method comprising the steps of:
- (a) amplifying a segment of a DNA from a patient, wherein said segment coxnpdses a region flanked by the genetic markers D4S1564 and D4S1572 on human chromosome 4;
- (b) comparing said segment with DNA corresponding to said segment obtained from an individual who is at least 98 years of age;
- and
- (c) identifying said patient as having propensity for longevity if said segment from said patient is identical to said segment from said individual who is at least 98 years of age.
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Dependencies are inferred from the claim text.